{"id":"W3191162253","doi":"10.1101/2021.08.09.455709","title":"Cell-to-cell variations in subcellular localisation of V2R are independent of its expression level","year":2021,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Institute for Research in Immunology and Cancer","funders":"Medical Research Council; University of Nottingham; Diabetes Canada","keywords":"Cell; Cell biology; Receptor; Endoplasmic reticulum; G protein-coupled receptor; Population; Biology; Intracellular; Mutant; Cell membrane; HEK 293 cells; Signal transduction; Biochemistry; Gene; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004734999,0.0003654161,0.0007667494,0.00039083,0.0003059017,0.001250517,0.0004379205,0.0006133734,0.002468223],"category_scores_gemma":[0.0008734742,0.0002877706,0.0004214112,0.0003068477,0.0004701149,0.0006089421,0.0007625344,0.0007806839,0.001332059],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000476881,"about_ca_system_score_gemma":0.000179077,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006959251,"about_ca_topic_score_gemma":0.0005537028,"domain_scores_codex":[0.9986424,0.0002111369,0.0001407813,0.0003842543,0.0004377993,0.0001834804],"domain_scores_gemma":[0.9986105,0.0005152376,0.0001991485,0.0002748237,0.0002551306,0.0001451548],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005116821,0.00001277787,0.0006354674,0.00001942578,0.000009063636,0.00002629071,0.00001445164,0.00005393175,0.998285,0.00005043631,0.00004151671,0.0008004315],"study_design_scores_gemma":[0.00001285651,0.0001711424,0.02995714,0.00000813535,0.00003121321,0.0004689831,0.00009093829,0.002273104,0.9647413,0.0001572535,0.002071279,0.00001663751],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9756274,0.002168142,0.01634235,0.0002295315,0.00009997078,0.00005699071,0.001458694,0.0002793195,0.003737658],"genre_scores_gemma":[0.9945802,0.0003476067,0.002266734,0.00010074,0.00001578348,0.00006961707,0.0006544098,0.0001100636,0.001854828],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002468223,"threshold_uncertainty_score":0.008257031,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01746220245999655,"score_gpt":0.214876025243142,"score_spread":0.1974138227831455,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}