{"id":"W3191178640","doi":"10.55563/clinexprheumatol/4rqeg0","title":"Tofacitinib inhibits CD4 T cell polarisation to Th1 during priming thereby leading to clinical impact in a model of experimental arthritis","year":2021,"lang":"en","type":"article","venue":"Clinical and Experimental Rheumatology","topic":"Rheumatoid Arthritis Research and Therapies","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"Versus Arthritis","keywords":"Tofacitinib; Medicine; Arthritis; Priming (agriculture); Janus kinase; T cell; Immunology; Immune system; Cytokine; Pharmacology; Cancer research; Rheumatoid arthritis; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001777272,0.0005289324,0.000417069,0.0002797753,0.0001537863,0.0002407599,0.0002149793,0.0003877239,0.001498509],"category_scores_gemma":[0.0001057802,0.00009905766,0.0002218339,0.0001648782,0.0002036113,0.0001828426,0.00007973282,0.001016407,0.0003007411],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002574192,"about_ca_system_score_gemma":0.0002384346,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002841151,"about_ca_topic_score_gemma":0.0005620804,"domain_scores_codex":[0.9998251,0.0000330773,0.00001362899,0.00002486467,0.00004679319,0.00005654454],"domain_scores_gemma":[0.9999287,0.00001442343,0.00002243731,0.000006374626,0.000009454478,0.00001865505],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007347066,0.0003774604,0.0001354493,0.0001605633,0.000009480715,0.0000543509,0.00001337591,0.0001835657,0.9924621,0.00005162306,0.0001094056,0.005707862],"study_design_scores_gemma":[0.0002448603,0.009576376,0.003047401,0.00002148882,0.00004420457,0.0003843856,0.00002540892,0.001134159,0.982206,0.00007189055,0.003236354,0.000007465243],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9871275,0.006510808,0.002254012,0.0002186782,0.0001588972,0.0001184103,0.000431788,0.0001689669,0.003010936],"genre_scores_gemma":[0.9931035,0.002658977,0.001453216,0.00008072148,0.00005845262,0.00008553153,0.0003416807,0.00001216089,0.002205775],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001498509,"threshold_uncertainty_score":0.005013049,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05508460454270066,"score_gpt":0.4074298707311051,"score_spread":0.3523452661884044,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}