{"id":"W3191219220","doi":"10.1200/jco.21.00662","title":"Amivantamab in EGFR Exon 20 Insertion–Mutated Non–Small-Cell Lung Cancer Progressing on Platinum Chemotherapy: Initial Results From the CHRYSALIS Phase I Study","year":2021,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Lung Cancer Treatments and Mutations","field":"Medicine","cited_by":632,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"National Institute for Health and Care Research; Manchester Biomedical Research Centre; Cedars-Sinai Medical Center","keywords":"Medicine; Rash; Lung cancer; Internal medicine; Population; Adverse effect; Epidermal growth factor receptor; Erlotinib; Oncology; Gastroenterology; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001093185,0.0007472862,0.0009632834,0.000295154,0.0002619028,0.0006095716,0.000385071,0.0005220934,0.0009968588],"category_scores_gemma":[0.000546868,0.000198622,0.0006704457,0.0002845763,0.0004326729,0.0004294438,0.0002302477,0.001319607,0.0002733868],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007642603,"about_ca_system_score_gemma":0.0007084376,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001241453,"about_ca_topic_score_gemma":0.003530309,"domain_scores_codex":[0.9996911,0.0001344975,0.00001901495,0.00004002485,0.00005230086,0.00006295263],"domain_scores_gemma":[0.9996106,0.000082342,0.0000623853,0.00003094204,0.00003617691,0.0001774142],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.2287443,0.05538278,0.03697156,0.001533009,0.002138589,0.001051158,0.0009793118,0.006353311,0.336647,0.0005045451,0.005465469,0.3242289],"study_design_scores_gemma":[0.1409514,0.6924888,0.1097673,0.00009499725,0.001499408,0.001688698,0.0002418386,0.003480696,0.04213567,0.0003555119,0.007233879,0.00006173753],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956774,0.002081613,0.0002272389,0.0001720837,0.00002161617,0.0003692168,0.0003092746,0.00003068509,0.001110901],"genre_scores_gemma":[0.9959462,0.001732841,0.0003745714,0.0001911087,0.00003855235,0.0001863965,0.0008037866,0.00001302329,0.0007133791],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001241453,"threshold_uncertainty_score":0.005781353,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1015364525497676,"score_gpt":0.5266134971143889,"score_spread":0.4250770445646213,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}