{"id":"W3191257070","doi":"10.3390/antiox10081232","title":"Pterostilbene Changes Epigenetic Marks at Enhancer Regions of Oncogenes in Breast Cancer Cells","year":2021,"lang":"en","type":"article","venue":"Antioxidants","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Enhancer; Epigenetics; Chromatin immunoprecipitation; Biology; DNA methylation; DNMT3B; Transcription factor; Cancer research; Enhancer RNAs; Epigenetic therapy; Pterostilbene; Genetics; Gene; Gene expression; Promoter; Resveratrol; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001023768,0.0001371965,0.0001846638,0.00005249738,0.00004199517,0.000008548878,0.0001052314,0.0001452732,0.0001472643],"category_scores_gemma":[0.00001524305,0.0001423297,0.00006700891,0.0001630801,0.00005826856,0.0000025853,0.0001300089,0.00004653049,0.000006307973],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002214854,"about_ca_system_score_gemma":0.00008807587,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001217486,"about_ca_topic_score_gemma":0.003122967,"domain_scores_codex":[0.9989943,0.00007184534,0.0002264058,0.0003468646,0.0001276979,0.0002328804],"domain_scores_gemma":[0.9993552,0.00001390765,0.0001116672,0.000319219,0.0001414817,0.00005855574],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003562978,0.00007284021,0.03760174,0.00003265969,0.00002614058,0.000007490931,0.00003804667,0.0001113945,0.9572193,0.000006957649,0.0001359845,0.004711806],"study_design_scores_gemma":[0.0003043635,0.00003942766,0.1508957,0.00005811798,0.00001418802,0.000004477001,0.00002214633,0.00001716192,0.8459727,0.00003841531,0.002497889,0.0001353569],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9882284,0.01031906,0.000202304,0.0003322895,0.000239598,0.00009664866,0.0001209449,0.000003909055,0.0004567882],"genre_scores_gemma":[0.9754671,0.02264215,0.0002672262,0.00009699017,0.0001342484,0.00001988666,0.00006655561,0.00002178681,0.001284089],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.113294,"threshold_uncertainty_score":0.5804037,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01161735632831735,"score_gpt":0.2682245328419403,"score_spread":0.256607176513623,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}