{"id":"W3191272206","doi":"10.3389/fmolb.2021.676349","title":"A Cross-Platform Metabolomics Comparison Identifies Serum Metabolite Signatures of Liver Fibrosis Progression in Chronic Hepatitis C Patients","year":2021,"lang":"en","type":"article","venue":"Frontiers in Molecular Biosciences","topic":"Metabolomics and Mass Spectrometry Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta; McMaster University","funders":"Natural Sciences and Engineering Research Council of Canada; Canada Foundation for Innovation; Genome Canada","keywords":"Metabolome; Metabolite; Metabolomics; Choline; Cirrhosis; Liver disease; Internal medicine; Receiver operating characteristic; Fibrosis; Medicine; Chemistry; Endocrinology; Biology; Chromatography","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003714697,0.0002437969,0.0005129335,0.0002846704,0.00009316646,0.00008005739,0.0003999755,0.000192489,0.00001294506],"category_scores_gemma":[0.0002469727,0.0002229532,0.0001590615,0.0008330723,0.0003994177,0.00003024059,0.0003488629,0.0001587486,7.025473e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005830577,"about_ca_system_score_gemma":0.0001885567,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001152279,"about_ca_topic_score_gemma":0.0005034151,"domain_scores_codex":[0.9978504,0.0001150789,0.000537739,0.0006486619,0.0003980313,0.0004500411],"domain_scores_gemma":[0.9991542,0.0000110155,0.0002436223,0.0003461237,0.0001800239,0.00006507889],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003617234,0.0001443822,0.5035343,0.00005233227,0.00005066486,0.000009713965,0.00009087829,0.0002431527,0.4917846,0.0001450635,0.0001881995,0.003720513],"study_design_scores_gemma":[0.0005377301,0.0001463409,0.3381265,0.00003572312,0.00002176269,7.404654e-7,0.0001010508,0.0005191753,0.6580604,0.0001984355,0.002044538,0.0002076367],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.941176,0.0556136,0.002019242,0.00003154793,0.0007032203,0.0002394066,0.00008115506,0.000006237707,0.0001295683],"genre_scores_gemma":[0.9779603,0.006121326,0.01558398,0.00005824069,0.00003405649,0.0000280823,0.0001007824,0.00001564517,0.00009756194],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1662758,"threshold_uncertainty_score":0.9091769,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007269010495986733,"score_gpt":0.2712062096868159,"score_spread":0.2639371991908291,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}