{"id":"W3191289200","doi":"10.1128/spectrum.00315-21","title":"Precision Response to the Rise of the SARS-CoV-2 B.1.1.7 Variant of Concern by Combining Novel PCR Assays and Genome Sequencing for Rapid Variant Detection and Surveillance","year":2021,"lang":"en","type":"article","venue":"Microbiology Spectrum","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":42,"is_retracted":false,"has_abstract":true,"ca_institutions":"Public Health Agency of Canada; University of Calgary; University of Alberta","funders":"Genome Alberta; Alberta Precision Laboratories; Genome Canada","keywords":"Computational biology; Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); Coronavirus disease 2019 (COVID-19); Genome; Genetics; Biology; 2019-20 coronavirus outbreak; Gene; Virology; Medicine; Outbreak","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001834456,0.0001562403,0.0004089382,0.00008466478,0.0001598324,0.00001715609,0.0001676437,0.0001551921,0.000003665499],"category_scores_gemma":[0.0008098977,0.0001008458,0.00008052603,0.0002993138,0.0002931109,0.00002749846,0.0002243463,0.0002377615,0.000001496265],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001149444,"about_ca_system_score_gemma":0.0002929958,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002136041,"about_ca_topic_score_gemma":0.0003351199,"domain_scores_codex":[0.9984304,0.0003986829,0.0003582,0.0004054455,0.00009133634,0.0003158762],"domain_scores_gemma":[0.9983484,0.0008917453,0.0001546572,0.000433458,0.0001501806,0.00002156431],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002161501,0.00005170899,0.001244607,0.00005462776,0.00009327519,0.00001349883,0.0006097328,0.00000130958,0.9950932,0.0000491924,0.0000898559,0.0005374388],"study_design_scores_gemma":[0.002132859,0.0007298107,0.0055972,0.00006086036,0.00003521619,0.000913383,0.0001702439,0.0003541266,0.9646046,0.0001216105,0.02517123,0.0001088321],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9864825,0.001865906,0.008038639,0.00242361,0.000172548,0.0007284696,0.0002170003,0.00001354651,0.00005776904],"genre_scores_gemma":[0.9963795,0.00002513951,0.0003311354,0.003145567,0.00004374215,0.00002331252,0.000005091166,0.0000197726,0.00002674362],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03048862,"threshold_uncertainty_score":0.4112372,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03651396689368965,"score_gpt":0.3013954110909906,"score_spread":0.2648814441973009,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}