{"id":"W3191289200","doi":"10.1128/spectrum.00315-21","title":"Precision Response to the Rise of the SARS-CoV-2 B.1.1.7 Variant of Concern by Combining Novel PCR Assays and Genome Sequencing for Rapid Variant Detection and Surveillance","year":2021,"lang":"en","type":"article","venue":"Microbiology Spectrum","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":42,"is_retracted":false,"has_abstract":true,"ca_institutions":"Public Health Agency of Canada; University of Calgary; University of Alberta","funders":"Genome Alberta; Alberta Precision Laboratories; Genome Canada","keywords":"Computational biology; Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); Coronavirus disease 2019 (COVID-19); Genome; Genetics; Biology; 2019-20 coronavirus outbreak; Gene; Virology; Medicine; Outbreak","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001026357,0.0004673256,0.0004138302,0.001201999,0.0002582149,0.0008274962,0.0004274758,0.0005854426,0.0006682876],"category_scores_gemma":[0.001799647,0.0002071036,0.0001915564,0.0007067376,0.0004739254,0.0002030909,0.0003026019,0.000426628,0.000287452],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00211492,"about_ca_system_score_gemma":0.001668134,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.1408871,"about_ca_topic_score_gemma":0.2379238,"domain_scores_codex":[0.9983796,0.0001822167,0.00004719582,0.0002874133,0.0009367781,0.0001667674],"domain_scores_gemma":[0.9986749,0.0002196202,0.0003129181,0.000054052,0.0006435802,0.0000949388],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009014872,0.0001766678,0.407651,0.0002657603,0.00008896461,0.0003147678,0.0007226004,0.002609871,0.4377671,0.0003612103,0.002132974,0.1470076],"study_design_scores_gemma":[0.00005594305,0.001286588,0.7641407,0.00007454781,0.0001533843,0.001014372,0.0008327087,0.01003144,0.2101547,0.0002473708,0.0119258,0.00008253736],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9663936,0.003695903,0.01837266,0.000604954,0.0001852248,0.0002220195,0.001529,0.0008249577,0.00817164],"genre_scores_gemma":[0.9774479,0.0008804818,0.01722287,0.0004065016,0.00003636127,0.00003701876,0.0006716205,0.00003482317,0.003262439],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1408871,"threshold_uncertainty_score":0.280134,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03651396689368965,"score_gpt":0.3013954110909906,"score_spread":0.2648814441973009,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}