{"id":"W3191358950","doi":"10.1016/j.bbadva.2021.100021","title":"The degree and position of phosphorylation determine the impact of toxic and trace metals on phosphoinositide containing model membranes","year":2021,"lang":"en","type":"article","venue":"BBA Advances","topic":"Lipid Membrane Structure and Behavior","field":"Biochemistry, Genetics and Molecular Biology","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Phosphatidylinositol; Membrane; Phosphatidylinositol 4,5-bisphosphate; Chemistry; Cobalt; Liposome; Biophysics; Cadmium; Second messenger system; Biochemistry; Phosphorylation; Signal transduction; Biology; Inorganic chemistry; Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001130204,0.0002548545,0.0001514665,0.00008624893,0.0001355522,0.0002445327,0.0001833825,0.0002636153,0.0007528174],"category_scores_gemma":[0.0002001854,0.0001283858,0.0001129658,0.0001068642,0.0001601304,0.0002444481,0.0001731983,0.00026093,0.0001958731],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002258436,"about_ca_system_score_gemma":0.0001531167,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008700851,"about_ca_topic_score_gemma":0.001074271,"domain_scores_codex":[0.9998672,0.00002214302,0.00001100377,0.00003628808,0.00003603398,0.00002734558],"domain_scores_gemma":[0.9999075,0.00003035446,0.00002400395,0.000006533541,0.00001861254,0.00001310741],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007445391,0.000007987803,0.0001217289,0.00002503929,0.00000271456,0.00001203001,0.00001094721,0.00008439066,0.9992467,0.00003131434,0.000005980717,0.0003766732],"study_design_scores_gemma":[0.000001903963,0.00007443436,0.0008331041,0.00000233701,0.000005156402,0.00002098923,0.00001530333,0.0004435178,0.9982969,0.00001475341,0.00028949,0.000002133979],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.997252,0.0004310518,0.001353493,0.00003754926,0.000007947445,0.00001060646,0.0001108508,0.00001530104,0.0007810653],"genre_scores_gemma":[0.9976466,0.0004498205,0.00105681,0.00001657696,0.000001730461,0.00001435046,0.0001203258,0.000006210649,0.0006873632],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008700851,"threshold_uncertainty_score":0.002518415,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01932475117696655,"score_gpt":0.2859413006527615,"score_spread":0.266616549475795,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}