{"id":"W3191486107","doi":"10.1016/j.jbc.2021.101042","title":"The HIV-1 accessory protein Nef increases surface expression of the checkpoint receptor Tim-3 in infected CD4+ T cells","year":2021,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Galectins and Cancer Biology","field":"Immunology and Microbiology","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; McGill University; Centre Hospitalier de l’Université de Montréal; Western University","funders":"National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; National Institutes of Health; Deutsche Forschungsgemeinschaft","keywords":"Downregulation and upregulation; Cell biology; Biology; Receptor; Immune checkpoint; Cytotoxic T cell; Immune system; Immunology; Immunotherapy; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001303769,0.0002294284,0.0002096847,0.0002135904,0.0001957366,0.0005387982,0.0001743368,0.0004513057,0.002837215],"category_scores_gemma":[0.0001839467,0.0001564928,0.000265788,0.0001361642,0.0001799108,0.0002657013,0.0002389843,0.001061509,0.0005200866],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004310111,"about_ca_system_score_gemma":0.0002366463,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004246258,"about_ca_topic_score_gemma":0.0006873636,"domain_scores_codex":[0.9998186,0.00003406145,0.000008871017,0.00002123517,0.00003364485,0.00008373489],"domain_scores_gemma":[0.9999013,0.00002613632,0.00001721159,0.00001300103,0.000009891414,0.00003255269],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005148416,0.00007678678,0.0003817044,0.00005148652,0.000008237702,0.00004595979,0.00002504359,0.00007592911,0.9963616,0.000117851,0.000192164,0.002148481],"study_design_scores_gemma":[0.0001618769,0.0009346484,0.02514936,0.000022367,0.00003456895,0.00042015,0.0002043446,0.001834098,0.9674544,0.0002854469,0.003483302,0.00001526175],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9964957,0.001125471,0.0003883662,0.0001105408,0.00005201837,0.00001572423,0.0002778938,0.00005507654,0.00147925],"genre_scores_gemma":[0.9970156,0.0004154017,0.0004650304,0.00006586639,0.00001554218,0.00001598763,0.0003031785,0.00001507021,0.001688346],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002837215,"threshold_uncertainty_score":0.009491444,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0133782816195282,"score_gpt":0.2320377505869329,"score_spread":0.2186594689674047,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}