{"id":"W3191569443","doi":"10.1016/j.jbc.2021.101057","title":"Lipidated peptides derived from intracellular loops 2 and 3 of the urotensin II receptor act as biased allosteric ligands","year":2021,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Cardiovascular, Neuropeptides, and Oxidative Stress Research","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Montreal Heart Institute; Université du Québec à Montréal; McGill University; Institut National de la Recherche Scientifique","funders":"Faculty of Medicine and Health, University of Sydney; Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research; Heart and Stroke Foundation of Canada; McGill University; Faculty of Medicine, McGill University; Natural Sciences and Engineering Research Council of Canada","keywords":"Urotensin-II; Allosteric regulation; Intracellular; Receptor; G protein-coupled receptor; Signal transduction; Allosteric modulator; Cell biology; Biology; Phosphorylation; Chemistry; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002761504,0.0001602403,0.0005784155,0.00002197502,0.00007545655,0.00002403106,0.0001697579,0.000177772,0.0006644629],"category_scores_gemma":[0.002264542,0.00008953385,0.0004054938,0.0002140379,0.0003308574,0.00003767316,0.0002531279,0.0005750804,0.000003555839],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003218693,"about_ca_system_score_gemma":0.0001831951,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00000911727,"about_ca_topic_score_gemma":4.713994e-7,"domain_scores_codex":[0.9986021,0.0001375185,0.0004511183,0.0002318623,0.0003843968,0.0001930252],"domain_scores_gemma":[0.9985136,0.0002171137,0.0002557311,0.0002964775,0.000517187,0.0001999392],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00049889,0.0001451906,0.007543484,0.00005187814,0.0003289379,0.0003346802,0.0000545184,0.000001622193,0.9885282,2.157947e-7,0.0004578827,0.002054533],"study_design_scores_gemma":[0.00134966,0.0002860465,0.04307286,0.0002755679,0.0001028829,0.0006057358,0.000220533,0.000007209193,0.9500217,0.00001871119,0.00394904,0.00009008814],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9950156,0.003552636,0.000009973867,0.000879576,0.0000727923,0.00008228374,0.00002760647,0.000006894089,0.0003526597],"genre_scores_gemma":[0.9963572,0.00239235,0.0002889024,0.0001791911,0.0003867746,0.000001022772,0.00002873063,0.00001132752,0.0003544861],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0385065,"threshold_uncertainty_score":0.7275402,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02992834225304367,"score_gpt":0.2655287838947126,"score_spread":0.2356004416416689,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}