{"id":"W3191569443","doi":"10.1016/j.jbc.2021.101057","title":"Lipidated peptides derived from intracellular loops 2 and 3 of the urotensin II receptor act as biased allosteric ligands","year":2021,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Cardiovascular, Neuropeptides, and Oxidative Stress Research","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Montreal Heart Institute; Université du Québec à Montréal; McGill University; Institut National de la Recherche Scientifique","funders":"Faculty of Medicine and Health, University of Sydney; Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research; Heart and Stroke Foundation of Canada; McGill University; Faculty of Medicine, McGill University; Natural Sciences and Engineering Research Council of Canada","keywords":"Urotensin-II; Allosteric regulation; Intracellular; Receptor; G protein-coupled receptor; Signal transduction; Allosteric modulator; Cell biology; Biology; Phosphorylation; Chemistry; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008224745,0.0001989314,0.0001195542,0.00005242326,0.00006188049,0.0001821912,0.0001031133,0.0001559221,0.001448019],"category_scores_gemma":[0.00007988869,0.0000630787,0.0001037004,0.00006773652,0.0001669774,0.0001333156,0.0001374757,0.0003866658,0.0002156245],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001484401,"about_ca_system_score_gemma":0.00008517471,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000132009,"about_ca_topic_score_gemma":0.0002659071,"domain_scores_codex":[0.9999617,0.000007809659,0.000002635756,0.000007063222,0.000008053838,0.00001260453],"domain_scores_gemma":[0.9999566,0.000009652444,0.00001249994,0.000003997431,0.000004023745,0.00001311958],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009744819,0.00001090945,0.00006510693,0.00001206615,0.000001278223,0.00003033702,0.000006048927,0.00004318299,0.9991394,0.00007261735,0.000009902938,0.0005115391],"study_design_scores_gemma":[0.000027217,0.0003495394,0.000948209,0.000002661012,0.000006906078,0.000123114,0.0000183576,0.0004423246,0.9966806,0.00003090022,0.001366357,0.000003846408],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976264,0.0002269189,0.001293285,0.0000325782,0.0000172619,0.00002029464,0.00008171777,0.00001679104,0.0006847871],"genre_scores_gemma":[0.9964676,0.0002363406,0.001825294,0.00004932777,0.000007372368,0.00001987205,0.0001682977,0.000008324339,0.001217635],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001448019,"threshold_uncertainty_score":0.004844069,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02992834225304367,"score_gpt":0.2655287838947126,"score_spread":0.2356004416416689,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}