{"id":"W3191668754","doi":"10.1124/molpharm.121.000294","title":"β2-Adrenoceptor Agonists Promote Extracellular Signal-Regulated Kinase 1/2 Dephosphorylation in Human Airway Epithelial Cells by Canonical, cAMP-Driven Signaling Independently of β-Arrestin 2","year":2021,"lang":"en","type":"article","venue":"Molecular Pharmacology","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Calgary","funders":"Canadian Institutes of Health Research","keywords":"Formoterol; Kinase; Cell biology; Biology; Phosphorylation; MAPK/ERK pathway; Protein kinase A; Signal transduction; Formoterol Fumarate; Beta adrenergic receptor kinase; Dephosphorylation; Endocrinology; Internal medicine; G protein-coupled receptor; Medicine; Phosphatase","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0004271726,0.0003885822,0.000495846,0.0001187913,0.0001330838,0.00003631175,0.0003575345,0.0005046683,0.002305705],"category_scores_gemma":[0.00003299858,0.0004490654,0.0002279177,0.0003072101,0.0001381431,0.00001124279,0.0002054798,0.0003729382,0.00001019284],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008175588,"about_ca_system_score_gemma":0.0003682346,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001319468,"about_ca_topic_score_gemma":0.00004372682,"domain_scores_codex":[0.9968852,0.0005263655,0.0007745671,0.0008638517,0.0003391484,0.0006108359],"domain_scores_gemma":[0.9988364,0.00002799669,0.0003357303,0.0003388958,0.0002526587,0.0002083011],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001361966,0.000405147,0.0001535406,0.00005166248,0.0001510269,0.0003020487,0.0001103289,0.007721266,0.9898298,0.00004633825,0.0004303661,0.0006622297],"study_design_scores_gemma":[0.00219506,0.0003670039,0.00002103117,0.00003486652,0.00009881082,0.00001773468,0.00004692975,0.001005515,0.9920639,0.000078533,0.003625962,0.0004446966],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9864591,0.002973953,0.009443437,0.00007536916,0.0003924909,0.0005031207,0.00007520032,0.00002362158,0.00005374319],"genre_scores_gemma":[0.9973249,0.00007947916,0.001127934,0.0001850763,0.0001404268,0.00005693313,0.0006326638,0.00008211529,0.0003704975],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01086581,"threshold_uncertainty_score":0.9997961,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006845915366163545,"score_gpt":0.2518747702832242,"score_spread":0.2450288549170607,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}