{"id":"W3191668754","doi":"10.1124/molpharm.121.000294","title":"β2-Adrenoceptor Agonists Promote Extracellular Signal-Regulated Kinase 1/2 Dephosphorylation in Human Airway Epithelial Cells by Canonical, cAMP-Driven Signaling Independently of β-Arrestin 2","year":2021,"lang":"en","type":"article","venue":"Molecular Pharmacology","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Calgary","funders":"Canadian Institutes of Health Research","keywords":"Formoterol; Kinase; Cell biology; Biology; Phosphorylation; MAPK/ERK pathway; Protein kinase A; Signal transduction; Formoterol Fumarate; Beta adrenergic receptor kinase; Dephosphorylation; Endocrinology; Internal medicine; G protein-coupled receptor; Medicine; Phosphatase","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001418094,0.0002209071,0.0001889339,0.0001703416,0.0001938662,0.0003232376,0.0001079119,0.0001703697,0.001876671],"category_scores_gemma":[0.00009409339,0.0002070313,0.000261946,0.0001356648,0.0001213058,0.0001537275,0.0001705602,0.0005481414,0.0006293488],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002663948,"about_ca_system_score_gemma":0.0002281953,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001216376,"about_ca_topic_score_gemma":0.002568952,"domain_scores_codex":[0.9998146,0.00004432623,0.0000159626,0.00002128334,0.00003541627,0.00006846799],"domain_scores_gemma":[0.9999574,0.00001304616,0.000005837827,0.000006740998,0.00000585001,0.00001109151],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000203554,0.00003269779,0.00009069737,0.00002292043,0.000003972966,0.00005817838,0.00001587264,0.00002147761,0.9988785,0.00006853598,0.0000958084,0.0005077597],"study_design_scores_gemma":[0.00004213836,0.0002596962,0.0137116,0.000006635933,0.00001096414,0.0002320759,0.00006120941,0.0005862653,0.9824336,0.00003730796,0.002614571,0.000003970872],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9920225,0.003115327,0.0008197002,0.0002177108,0.00006295319,0.00004418374,0.0006909398,0.00004565603,0.002980998],"genre_scores_gemma":[0.9922028,0.001647332,0.0006377932,0.0001356699,0.00002311506,0.00005515092,0.00095824,0.00001209111,0.004327894],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001876671,"threshold_uncertainty_score":0.006278098,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006845915366163545,"score_gpt":0.2518747702832242,"score_spread":0.2450288549170607,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}