{"id":"W3191673291","doi":"10.1016/j.chembiol.2021.07.010","title":"Chemogenomics identifies acetyl-coenzyme A synthetase as a target for malaria treatment and prevention","year":2021,"lang":"en","type":"article","venue":"Cell chemical biology","topic":"Malaria Research and Control","field":"Medicine","cited_by":81,"is_retracted":false,"has_abstract":true,"ca_institutions":"Structural Genomics Consortium; McGill University Health Centre","funders":"National Institute of General Medical Sciences; National Health and Medical Research Council; National Institute of Allergy and Infectious Diseases; Medical Research Council; Huck Institutes of the Life Sciences; National Institutes of Health; Global Health Innovative Technology Fund; University of Dundee; Medicines for Malaria Venture; Harvard T.H. Chan School of Public Health; National Institute of Diabetes and Digestive and Kidney Diseases; Bill and Melinda Gates Foundation; Pennsylvania State University; Wellcome Trust; University of Pennsylvania","keywords":"Druggability; Gene knockdown; Biology; Acetylation; Epigenetics; Gene; Enzyme; Biochemistry; In vitro; Plasmodium falciparum; Genetics; Cell biology; Malaria","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001532267,0.0002688268,0.0002677893,0.0002329472,0.0001481149,0.0002875852,0.0001952442,0.000261356,0.00139614],"category_scores_gemma":[0.0001161633,0.0001130097,0.000210569,0.0001953667,0.0002301992,0.000139834,0.0001380011,0.000308598,0.0002822275],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004673262,"about_ca_system_score_gemma":0.000362103,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001241367,"about_ca_topic_score_gemma":0.001970835,"domain_scores_codex":[0.999915,0.00001207091,0.000004111937,0.00002235243,0.0000314203,0.0000150141],"domain_scores_gemma":[0.9999316,0.00001010214,0.00002051999,0.000009031486,0.00001668779,0.00001206457],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007054764,0.00001429616,0.000651004,0.00003868701,0.000005167722,0.00002936729,0.00000592732,0.000168374,0.9928672,0.0002246967,0.00009153019,0.005833061],"study_design_scores_gemma":[0.0000153264,0.0004300269,0.008147217,0.000007492948,0.00002051922,0.0002561948,0.00001654606,0.001771572,0.9834567,0.0001604796,0.005712733,0.000005183848],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9632482,0.01086718,0.01653159,0.001612446,0.00008129684,0.0001022004,0.001233904,0.0003099283,0.006013174],"genre_scores_gemma":[0.9871446,0.003117423,0.006612087,0.0001754127,0.00002269694,0.00002579446,0.0004848908,0.00001472718,0.002402394],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00139614,"threshold_uncertainty_score":0.00467056,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01784824987856701,"score_gpt":0.293619522841807,"score_spread":0.27577127296324,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}