{"id":"W3191770147","doi":"10.1002/1878-0261.13080","title":"ERK signaling controls productive HIF‐1 binding to chromatin and cancer cell adaptation to hypoxia through HIF‐1α interaction with NPM1","year":2021,"lang":"en","type":"article","venue":"Molecular Oncology","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Hellenic Foundation for Research and Innovation","keywords":"Chromatin; Cell biology; Biology; Gene silencing; Hypoxia (environmental); Histone; Downregulation and upregulation; Regulation of gene expression; MAPK/ERK pathway; Phosphorylation; Cancer research; Chemistry; Gene; Biochemistry; Oxygen","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005981863,0.0001727202,0.0001128759,0.0001282001,0.0001377096,0.0001974881,0.0001160539,0.00009624319,0.0008275664],"category_scores_gemma":[0.00007120256,0.00008273232,0.00008551122,0.0001048637,0.0001220296,0.0001361816,0.0001813121,0.0001612079,0.0002299717],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002600235,"about_ca_system_score_gemma":0.0001466839,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000452489,"about_ca_topic_score_gemma":0.0005966898,"domain_scores_codex":[0.9999459,0.000008273535,0.000002262881,0.00001220198,0.00001232539,0.00001911778],"domain_scores_gemma":[0.9999672,0.00000339509,0.00001218042,0.0000024164,0.000005083451,0.000009666678],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001493832,0.00002369714,0.0007239753,0.0000341326,0.000002764267,0.00004545385,0.00001003337,0.0001679505,0.9964185,0.0002477259,0.00008046556,0.002095877],"study_design_scores_gemma":[0.00001923656,0.0000886972,0.05418885,0.000007996859,0.00001112588,0.0003695685,0.00005695008,0.006192024,0.9328077,0.0002743627,0.005977345,0.000006155831],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9928291,0.001912688,0.00241491,0.000108869,0.00001415763,0.00001437315,0.0002955346,0.00007245081,0.002337911],"genre_scores_gemma":[0.9966446,0.0005897204,0.0006698212,0.0000198695,0.000004200453,0.00001140892,0.0002704186,0.00000765499,0.001782431],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008275664,"threshold_uncertainty_score":0.002768517,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0142452734538414,"score_gpt":0.2857566452456718,"score_spread":0.2715113717918304,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}