{"id":"W3191871869","doi":"10.1038/s41380-021-01255-2","title":"Neuron-derived extracellular vesicles enriched from plasma show altered size and miRNA cargo as a function of antidepressant drug response","year":2021,"lang":"en","type":"article","venue":"Molecular Psychiatry","topic":"Extracellular vesicles in disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":104,"is_retracted":false,"has_abstract":false,"ca_institutions":"McMaster University; University Health Network; University of Toronto; St. Michael's Hospital; McGill University; Douglas Mental Health University Institute","funders":"Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research; Government of Canada","keywords":"Extracellular; Antidepressant; microRNA; Biomarker; Escitalopram; Pharmacology; Extracellular vesicle; Neuron; Citalopram; Fold change; Gene knockdown; Biology; Internal medicine; Endocrinology; Neuroscience; Medicine; Cell biology; Microvesicles; Hippocampus; Cell culture; Downregulation and upregulation; Biochemistry; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002681566,0.0003728052,0.0003496702,0.00005888909,0.0001055249,0.00006067528,0.0002894776,0.000208174,0.00008292638],"category_scores_gemma":[0.0005179818,0.0004249821,0.0002662367,0.0001774059,0.0001858872,0.00001330747,0.0002707587,0.0002121041,0.00001219517],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001264327,"about_ca_system_score_gemma":0.0003336698,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003607985,"about_ca_topic_score_gemma":0.00003331315,"domain_scores_codex":[0.9971802,0.0006513275,0.0004992351,0.0009572713,0.000336106,0.0003758507],"domain_scores_gemma":[0.9981682,0.00008997133,0.0002415746,0.001105609,0.0001447175,0.0002499494],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002245711,0.0003222957,0.006307763,0.00006446554,0.0002494031,0.0001916378,0.0000790949,0.00005683006,0.9889109,0.000156568,0.0008192513,0.000596073],"study_design_scores_gemma":[0.002255485,0.0002560463,0.08418732,0.00005469462,0.0002339512,0.00006549788,0.0003399876,0.0001049028,0.9081507,0.001317886,0.00255033,0.0004831998],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9674898,0.02898088,0.001603293,0.0007211291,0.0006930456,0.0002654988,0.0000872818,0.00003459986,0.0001244236],"genre_scores_gemma":[0.9929661,0.0002398637,0.005363399,0.0005195317,0.0001948021,0.00002429337,0.0001902954,0.0000920169,0.0004096752],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08076021,"threshold_uncertainty_score":0.9998202,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004852816438489518,"score_gpt":0.2197695945331542,"score_spread":0.2149167780946647,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}