{"id":"W3191953214","doi":"10.3390/cells10082024","title":"Calpain-Mediated Mitochondrial Damage: An Emerging Mechanism Contributing to Cardiac Disease","year":2021,"lang":"en","type":"review","venue":"Cells","topic":"Calpain Protease Function and Regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":47,"is_retracted":false,"has_abstract":true,"ca_institutions":"London Health Sciences Centre; Lawson Health Research Institute; University of Toronto; Western University","funders":"Natural Sciences and Engineering Research Council of Canada; Priority Academic Program Development of Jiangsu Higher Education Institutions","keywords":"Calpain; Mitochondrion; Proteases; Cell biology; Disease; Mechanism (biology); Inflammation; Biology; Autophagy; Programmed cell death; Apoptosis; Neuroscience; Medicine; Immunology; Pathology; Biochemistry; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003445634,0.0003815718,0.0007771082,0.0000942608,0.000177566,0.00007739485,0.0001958687,0.0004169368,0.0001029955],"category_scores_gemma":[0.0003207449,0.0003573587,0.0005836163,0.0002260001,0.00002567985,0.000003805652,0.0002359383,0.0002016498,0.00008224652],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005894061,"about_ca_system_score_gemma":0.0004158155,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000006986984,"about_ca_topic_score_gemma":0.000002831568,"domain_scores_codex":[0.9976591,0.0004862121,0.0004337359,0.0007566641,0.0002146072,0.000449709],"domain_scores_gemma":[0.9984556,0.00003746473,0.0001837076,0.0006544318,0.0001628781,0.0005059234],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001553611,0.0003382134,0.000006781209,0.007000948,0.001015473,0.0001724312,0.00009035847,0.0001351538,0.1283817,0.00067533,0.03230847,0.8297198],"study_design_scores_gemma":[0.000196694,0.00005532151,0.000001559051,0.0009117792,0.000365245,0.000001942417,0.00002257512,0.00002981936,0.001860065,0.000007152806,0.9961103,0.0004375263],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001996555,0.9897353,0.005275839,0.00003876354,0.002990594,0.001245582,0.0004114733,0.00004309775,0.00005966481],"genre_scores_gemma":[0.00009839208,0.9806923,0.0003951393,0.0002077299,0.003171696,0.0002199728,0.01119143,0.0001102017,0.003913131],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9638019,"threshold_uncertainty_score":0.9998878,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01875238737116628,"score_gpt":0.3047898590076892,"score_spread":0.2860374716365229,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}