{"id":"W3191953214","doi":"10.3390/cells10082024","title":"Calpain-Mediated Mitochondrial Damage: An Emerging Mechanism Contributing to Cardiac Disease","year":2021,"lang":"en","type":"review","venue":"Cells","topic":"Calpain Protease Function and Regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":47,"is_retracted":false,"has_abstract":true,"ca_institutions":"London Health Sciences Centre; Lawson Health Research Institute; University of Toronto; Western University","funders":"Natural Sciences and Engineering Research Council of Canada; Priority Academic Program Development of Jiangsu Higher Education Institutions","keywords":"Calpain; Mitochondrion; Proteases; Cell biology; Disease; Mechanism (biology); Inflammation; Biology; Autophagy; Programmed cell death; Apoptosis; Neuroscience; Medicine; Immunology; Pathology; Biochemistry; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003104459,0.0007295576,0.001058712,0.00160803,0.0002608178,0.001027757,0.0008110965,0.001215294,0.002993047],"category_scores_gemma":[0.0003433416,0.0001731995,0.0003013625,0.001518437,0.0004090351,0.00118277,0.0007479303,0.001601744,0.001834219],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000537347,"about_ca_system_score_gemma":0.0007390044,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005019418,"about_ca_topic_score_gemma":0.0008023125,"domain_scores_codex":[0.9999037,0.00001264924,0.00001219045,0.00001936831,0.00003772119,0.00001444958],"domain_scores_gemma":[0.9998852,0.00003754872,0.00001850051,0.000004314219,0.00003486254,0.00001964543],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001040763,0.00006562308,0.0001780898,0.0160737,0.00008283818,0.0005486084,0.00008406257,0.0003554699,0.005563654,0.00716714,0.04394729,0.9258294],"study_design_scores_gemma":[0.00001860934,0.0001013217,0.0008392492,0.002448535,0.00008543039,0.002789363,0.00006994003,0.0001051253,0.0007674618,0.003446033,0.9893122,0.00001673787],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001316322,0.9985129,0.000145876,0.0002807043,0.0001933804,0.000002345871,0.00001469464,0.000010058,0.0007082772],"genre_scores_gemma":[0.0005959718,0.9985464,0.0001146758,0.000137525,0.0001600629,0.000002829169,0.00002037303,0.000001167233,0.0004209631],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002993047,"threshold_uncertainty_score":0.01001275,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01875238737116628,"score_gpt":0.3047898590076892,"score_spread":0.2860374716365229,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}