{"id":"W3192033934","doi":"10.1073/pnas.2103671118","title":"miR-122–based therapies select for three distinct resistance mechanisms based on alterations in RNA structure","year":2021,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Hepatitis C virus research","field":"Medicine","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Canadian Institutes of Health Research; Canada Foundation for Innovation; National Institute of General Medical Sciences; Natural Sciences and Engineering Research Council of Canada; Government of Canada","keywords":"microRNA; RNA; Mechanism (biology); Biology; Virology; Virus; RNA silencing; Computational biology; RNA interference; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002000499,0.0002913228,0.000307185,0.0002122809,0.0001390418,0.0004352294,0.0001730342,0.0002860391,0.0008388491],"category_scores_gemma":[0.0002625693,0.0001272026,0.0002130957,0.0001167776,0.0002098637,0.0001696824,0.0001372543,0.0004606649,0.0003029699],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001773563,"about_ca_system_score_gemma":0.00009224547,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001079017,"about_ca_topic_score_gemma":0.0001843763,"domain_scores_codex":[0.9998129,0.00003160177,0.00001560631,0.00003859613,0.00007468517,0.00002656298],"domain_scores_gemma":[0.9998864,0.00002310706,0.0000414827,0.00001577438,0.00001535289,0.00001787995],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005330199,0.00003346023,0.0006248544,0.00001342823,0.000007434269,0.00003299014,0.00001153119,0.00005591986,0.9959587,0.00009684032,0.00002611909,0.003085262],"study_design_scores_gemma":[0.00001662911,0.0007384969,0.006994729,0.000004705237,0.00003101707,0.0007456388,0.00001889501,0.001418606,0.9875026,0.00007241636,0.002448668,0.000007576106],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9909695,0.001346026,0.005064087,0.00007452459,0.00002319022,0.00008384028,0.000142812,0.0000996711,0.002196414],"genre_scores_gemma":[0.9938886,0.0005976454,0.003736632,0.00007871593,0.00001333916,0.00003520239,0.0003321256,0.00001943171,0.00129815],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008388491,"threshold_uncertainty_score":0.002806246,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06139655603415965,"score_gpt":0.3557033075841626,"score_spread":0.2943067515500029,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}