{"id":"W3192152300","doi":"10.3233/jad-210173","title":"Grey Matter Loss at Different Stages of Cognitive Decline: A Role for the Thalamus in Developing Alzheimer’s Disease","year":2021,"lang":"en","type":"article","venue":"Journal of Alzheimer s Disease","topic":"Dementia and Cognitive Impairment Research","field":"Medicine","cited_by":102,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; National Institutes of Health; Genentech; IXICO; H. Lundbeck A/S; Servier; Eisai; Northern California Institute for Research and Education; BioClinica; F. Hoffmann-La Roche; University of Southern California; Biogen; U.S. Department of Defense; Meso Scale Diagnostics; Alzheimer's Disease Neuroimaging Initiative; Novartis Pharmaceuticals Corporation; Pfizer; Eli Lilly and Company; Bristol-Myers Squibb; National Institute on Aging; Alzheimer's Association; Foundation for the National Institutes of Health","keywords":"Grey matter; Dementia; Psychology; Neuroimaging; Thalamus; Neuroscience; Angular gyrus; Voxel-based morphometry; Cognitive decline; Clinical Dementia Rating; Alzheimer's disease; Lingual gyrus; Disease; Cognition; Audiology; Medicine; Magnetic resonance imaging; Cognitive impairment; Internal medicine; White matter; Radiology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0003967173,0.0002501861,0.000504909,0.0002057468,0.0001115602,0.00005128917,0.0001890021,0.00004525937,0.0009244747],"category_scores_gemma":[0.0004958196,0.0001624234,0.0004757982,0.0002363645,0.0001771564,0.0001796599,0.0002502096,0.0002583619,0.00001877235],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000635847,"about_ca_system_score_gemma":0.0007678607,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000007357567,"about_ca_topic_score_gemma":0.00001462503,"domain_scores_codex":[0.9974937,0.0001856372,0.0007494286,0.0002742268,0.0008606212,0.0004364001],"domain_scores_gemma":[0.9969996,0.0006103418,0.0003613343,0.0002424565,0.001160872,0.0006253851],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.005299898,0.001095526,0.9845678,0.0001264423,0.001959906,0.001240819,0.0002159083,0.000004563835,0.0002975204,0.00003579085,0.0006756202,0.004480251],"study_design_scores_gemma":[0.004998145,0.0002283087,0.9750082,0.000863247,0.005150928,0.00005201713,0.0005408566,0.00009311213,0.01197813,0.0004033257,0.0005073059,0.0001763926],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9501793,0.03854381,0.000322523,0.009720257,0.0001597696,0.0008260353,0.0001397651,0.000005877038,0.0001026929],"genre_scores_gemma":[0.9966738,0.0008512917,0.0001282017,0.001813087,0.0001947067,0.00008008142,0.00005809512,0.00003696541,0.0001637491],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04649455,"threshold_uncertainty_score":0.9999888,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03842529193191177,"score_gpt":0.3462367877360335,"score_spread":0.3078114958041217,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}