{"id":"W3192173765","doi":"10.1101/2021.08.04.454987","title":"Local regulation of extracellular vesicle traffic by the synaptic endocytic machinery","year":2021,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Cellular transport and secretion","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Institute of Neurological Disorders and Stroke; Natural Sciences and Engineering Research Council of Canada; National Institutes of Health","keywords":"Endocytic cycle; Endosome; Cell biology; Synaptic vesicle; Synaptic vesicle recycling; Retromer; Endocytosis; Biology; Synaptic plasticity; Dynamin; Synaptotagmin 1; Chemistry; Intracellular; Vesicle; Biochemistry; Cell","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000133383,0.0002512378,0.0002245743,0.0002532539,0.0002059982,0.0005843499,0.0002311613,0.0002371688,0.0008800917],"category_scores_gemma":[0.0001562868,0.0001380771,0.0001734052,0.0001244263,0.000377919,0.0003736138,0.0004688187,0.0003215221,0.0006408163],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004708785,"about_ca_system_score_gemma":0.0001694127,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002506973,"about_ca_topic_score_gemma":0.0002897779,"domain_scores_codex":[0.9998894,0.00001102124,0.00000732471,0.0000313887,0.00003695814,0.00002399331],"domain_scores_gemma":[0.9999115,0.0000118134,0.00002026694,0.00002324033,0.00001225232,0.00002086451],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003594127,0.000007503305,0.000404343,0.0000197975,0.000003923677,0.0001084455,0.000008310044,0.0002111552,0.9962822,0.001517514,0.00006999558,0.001330854],"study_design_scores_gemma":[0.00001476081,0.00002878753,0.007634785,0.000008906444,0.000007768072,0.0002610103,0.00003221727,0.006221399,0.9829317,0.0008487015,0.002003278,0.000006671452],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9759533,0.001285467,0.01631402,0.0001917338,0.00005089281,0.00001732084,0.000200096,0.000325126,0.005662058],"genre_scores_gemma":[0.9939382,0.0003882769,0.002646437,0.00002049386,0.00001161811,0.00001304614,0.0001378327,0.00005004063,0.002794017],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008800917,"threshold_uncertainty_score":0.003416479,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007007292240221748,"score_gpt":0.1911883858747434,"score_spread":0.1841810936345216,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}