{"id":"W3192226057","doi":"10.1016/j.dld.2021.07.008","title":"Clinical efficacy, drug sustainability and serum drug levels in Crohn's disease patients treated with ustekinumab – A prospective, multicenter cohort from Hungary","year":2021,"lang":"en","type":"article","venue":"Digestive and Liver Disease","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University; Montreal General Hospital","funders":"Nemzeti Kutatási Fejlesztési és Innovációs Hivatal; National Research, Development and Innovation Office; Emberi Eroforrások Minisztériuma; Nemzeti Kutatási és Technológiai Hivatal","keywords":"Medicine; Ustekinumab; Internal medicine; Crohn's disease; Prospective cohort study; Clinical trial; Population; Inflammatory bowel disease; Cohort; Drug; Disease; Gastroenterology; Pharmacology; Adalimumab","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001150552,0.0003240384,0.0002790301,0.00004073016,0.0001416213,0.0000540049,0.0001020748,0.00007574834,0.00002537893],"category_scores_gemma":[0.0004490587,0.0002916474,0.0001081614,0.00008869184,0.0004368101,0.0000328547,0.0002694294,0.0001654498,0.00000334545],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006564899,"about_ca_system_score_gemma":0.0004981499,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001375483,"about_ca_topic_score_gemma":0.0001921996,"domain_scores_codex":[0.9976922,0.0004088347,0.0003141547,0.001039034,0.0002040284,0.0003417942],"domain_scores_gemma":[0.9981734,0.00008042772,0.00009716706,0.0004560333,0.0004162246,0.0007767596],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.005419308,0.0013806,0.9876891,0.00008447005,0.0001414841,0.004282909,0.0002201734,0.00001328337,0.00001282741,0.000007767913,0.0001128974,0.0006351263],"study_design_scores_gemma":[0.005319269,0.00004556103,0.9934203,0.00007907878,0.0002199165,8.249294e-7,0.000138244,0.0001336563,0.00007107024,0.00003278075,0.0001523498,0.0003869162],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9967456,0.0008937555,0.000005996952,0.00007300392,0.00003804625,0.001150822,0.001023281,0.00002116779,0.00004833365],"genre_scores_gemma":[0.9983831,0.0001893861,0.00003517009,0.0002660916,0.00006541186,0.0000877747,0.0006249898,0.00003513044,0.0003129482],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005731179,"threshold_uncertainty_score":0.9999536,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005805941706943873,"score_gpt":0.2439012229786798,"score_spread":0.238095281271736,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}