{"id":"W3192258571","doi":"10.1101/2021.08.09.455606","title":"ACE2 is the critical <i>in vivo</i> receptor for SARS-CoV-2 in a novel COVID-19 mouse model with TNF- and IFNγ-driven immunopathology","year":2021,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Canadian Institutes of Health Research; Universität für Bodenkultur Wien; Medizinische Universität Wien; Austrian Science Fund; Innovative Medicines Initiative; Universität Wien; Österreichischen Akademie der Wissenschaften","keywords":"Immunology; Immunopathology; Proinflammatory cytokine; Immune system; Cytokine; Biology; Tumor necrosis factor alpha; Pneumonia; In vivo; Inflammation; Immunity; Virology; Medicine; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00035077,0.001419669,0.0005026191,0.0006279318,0.0003033286,0.0006857903,0.0004656909,0.001019992,0.002594164],"category_scores_gemma":[0.00013148,0.0004020366,0.0007723428,0.0002384855,0.0006891264,0.0006301086,0.0002943613,0.002640505,0.001055309],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005653457,"about_ca_system_score_gemma":0.0003252262,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000529768,"about_ca_topic_score_gemma":0.0007482279,"domain_scores_codex":[0.9995524,0.0000786632,0.00006102488,0.0001106982,0.0001039721,0.00009320566],"domain_scores_gemma":[0.9995884,0.00003079088,0.0001719132,0.00004827611,0.00002501059,0.0001354936],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002825739,0.0001063613,0.000200913,0.00003545905,0.000007475871,0.0001065626,0.00001622668,0.00008781816,0.998467,0.000194103,0.00006577208,0.0004296745],"study_design_scores_gemma":[0.0001311796,0.001964776,0.005249818,0.00003189672,0.0000496691,0.001630689,0.0001088589,0.002010974,0.9834784,0.0002124671,0.005115207,0.0000160576],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9856693,0.001199962,0.007751912,0.0004974223,0.0001491162,0.0001663189,0.002106018,0.0002707976,0.002189117],"genre_scores_gemma":[0.9778864,0.001132316,0.008515983,0.0002560429,0.00005411898,0.0002500843,0.002606308,0.0001520557,0.009146835],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002594164,"threshold_uncertainty_score":0.008678377,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.046597524981132,"score_gpt":0.3234402529342446,"score_spread":0.2768427279531125,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}