{"id":"W3192478464","doi":"10.1038/s41467-021-25228-9","title":"Spontaneous hydrolysis and spurious metabolic properties of α-ketoglutarate esters","year":2021,"lang":"en","type":"article","venue":"Nature Communications","topic":"ATP Synthase and ATPases Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":40,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Institute of General Medical Sciences; Stand Up To Cancer; Lustgarten Foundation; National Cancer Institute; U.S. Department of Health and Human Services; National Institutes of Health; American Cancer Society","keywords":"Cytosol; Metabolism; Glycolysis; Biochemistry; Chemistry; Mitochondrion; Bioenergetics; Cellular respiration; Extracellular; Hydrolysis; Catabolism; Cell; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000156754,0.00031205,0.0002357855,0.0001240463,0.00008886347,0.0003755859,0.0002200484,0.000332636,0.0007733204],"category_scores_gemma":[0.0003040805,0.0001464288,0.0002330236,0.00012272,0.0002156986,0.0003575442,0.0003640885,0.0004166758,0.0002867953],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001347505,"about_ca_system_score_gemma":0.00009641845,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002155693,"about_ca_topic_score_gemma":0.0002399285,"domain_scores_codex":[0.999799,0.00003877034,0.00002416361,0.00005526344,0.00005183683,0.00003097545],"domain_scores_gemma":[0.9997796,0.00005333275,0.00006203073,0.00004746156,0.0000270642,0.00003059939],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007899713,0.000004581302,0.000240344,0.00002202782,0.000004658691,0.0001034954,0.00001241199,0.00003771552,0.9987481,0.00008158168,0.00001204558,0.0006540093],"study_design_scores_gemma":[0.000003580783,0.00006658008,0.001857029,0.000003024284,0.000004591581,0.0003283997,0.00002168313,0.0003364852,0.9964848,0.00005718145,0.000832882,0.000003695352],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9874879,0.00218585,0.007894122,0.00008580767,0.00003693471,0.0000237007,0.0004178607,0.0000724973,0.001795317],"genre_scores_gemma":[0.9961869,0.0005056702,0.001536636,0.00003860729,0.000005649145,0.00001868312,0.0004909467,0.00002525328,0.001191568],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007733204,"threshold_uncertainty_score":0.002586961,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0184674566665235,"score_gpt":0.2919283182274375,"score_spread":0.273460861560914,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}