{"id":"W3192590880","doi":"10.1128/msystems.00306-21","title":"Species-Specific Endotoxin Stimulus Determines Toll-Like Receptor 4- and Caspase 11-Mediated Pathway Activation Characteristics","year":2021,"lang":"en","type":"article","venue":"mSystems","topic":"Immune Response and Inflammation","field":"Immunology and Microbiology","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Allergy and Infectious Diseases; Genome Canada; Division of Intramural Research, National Institute of Allergy and Infectious Diseases; American Association of Pharmaceutical Scientists","keywords":"Stimulus (psychology); Toll-like receptor; Receptor; Cell biology; Toll; Chemistry; Communication; Biology; Neuroscience; Innate immune system; Immunology; Psychology; Genetics; Cognitive psychology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001268063,0.0001708365,0.0001627272,0.0002318619,0.0001174646,0.0003172334,0.00009984335,0.0002586515,0.004821908],"category_scores_gemma":[0.0002155296,0.00009475203,0.0002469624,0.0001186612,0.0001721735,0.0002915026,0.0001863931,0.0005989667,0.0009584964],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001821638,"about_ca_system_score_gemma":0.0001681716,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008792423,"about_ca_topic_score_gemma":0.0001486814,"domain_scores_codex":[0.9997646,0.00002987666,0.00002250872,0.00005253607,0.00003663938,0.00009388846],"domain_scores_gemma":[0.999821,0.00002242638,0.00004343444,0.00001746828,0.00002421312,0.00007153975],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003889003,0.00003854739,0.0005264517,0.00003928233,0.000002888139,0.00006978553,0.000021135,0.00001360986,0.9977878,0.0001135348,0.00006266629,0.000935276],"study_design_scores_gemma":[0.00004862588,0.00074078,0.07457761,0.00002589776,0.00001699006,0.001532054,0.0002361134,0.0007655584,0.9163641,0.0003855359,0.005291194,0.00001543768],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9930143,0.001723616,0.001971998,0.0001431273,0.00008163685,0.00003580128,0.0006664315,0.000047955,0.002315211],"genre_scores_gemma":[0.9942144,0.0006025071,0.001350814,0.00007071797,0.00001558849,0.00004765726,0.0009828819,0.00001299066,0.002702529],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004821908,"threshold_uncertainty_score":0.01613086,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01452351191918708,"score_gpt":0.2049732834939146,"score_spread":0.1904497715747276,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}