{"id":"W3192620725","doi":"10.1038/s41467-021-25088-3","title":"Chd1 protects genome integrity at promoters to sustain hypertranscription in embryonic stem cells","year":2021,"lang":"en","type":"article","venue":"Nature Communications","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; University of Toronto","funders":"CIHR Skin Research Training Centre; National Cancer Institute; Alexander von Humboldt-Stiftung; Medical Research Council; Manchester Biomedical Research Centre; Cancer Research UK; University of California, San Francisco; Blood Cancer UK; Canadian Institutes of Health Research; National Institute of General Medical Sciences; National Institute for Health and Care Research; National Institutes of Health; U.S. Department of Health and Human Services; Government of Canada","keywords":"Embryonic stem cell; Stem cell; Promoter; Genome; Biology; Cell biology; Genetics; Computational biology; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001549036,0.0001092197,0.0001015711,0.00005359254,0.0000862762,0.00001904874,0.0004127415,0.0002626787,0.000006500789],"category_scores_gemma":[0.00003836972,0.0001177418,0.00005637644,0.0002327391,0.00002527388,0.00000294104,0.0003218467,0.0005037344,0.00000928923],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008176238,"about_ca_system_score_gemma":0.00008373177,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000009742918,"about_ca_topic_score_gemma":0.001400421,"domain_scores_codex":[0.9992673,0.00009404365,0.000139145,0.0002382865,0.00007681376,0.0001844181],"domain_scores_gemma":[0.9986588,0.00001249328,0.0000221448,0.001127963,0.0001109887,0.00006755831],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001355444,0.00005967896,0.0002002759,0.00002184641,0.00001303176,0.000002100484,0.0001797686,0.0003117819,0.9980443,0.0001007375,0.0003180912,0.0007348098],"study_design_scores_gemma":[0.0003284444,0.00007931911,0.00679712,0.00002990458,0.00001061412,0.00001786994,0.0002914169,0.0002161732,0.7983225,0.00001588699,0.1936612,0.0002295573],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9792283,0.01264908,0.002323892,0.004443258,0.0001371772,0.0005879464,0.00002951575,0.00002543843,0.0005754462],"genre_scores_gemma":[0.9940307,0.0005413658,0.003814948,0.0002953614,0.00003343847,0.00008780926,0.0001444458,0.0000175913,0.001034379],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1997218,"threshold_uncertainty_score":0.4801372,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0132607967996389,"score_gpt":0.2989350672914654,"score_spread":0.2856742704918265,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}