{"id":"W3192670554","doi":"10.1021/acsnano.1c04510","title":"Specific Endothelial Cells Govern Nanoparticle Entry into Solid Tumors","year":2021,"lang":"en","type":"article","venue":"ACS Nano","topic":"Extracellular vesicles in disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":127,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada Research Chairs; University of Toronto","funders":"Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs; Canadian Cancer Society","keywords":"Tumor microenvironment; Nanoparticle; Endothelial stem cell; Cancer research; Tumor cells; Cell biology; Chemistry; Nanotechnology; Materials science; Biophysics; Medicine; Biology; In vitro; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00021046,0.0001375072,0.0002211632,0.0001814117,0.0001616144,0.0005644756,0.0001282357,0.0002935208,0.001028541],"category_scores_gemma":[0.0003949807,0.0001265669,0.0001573704,0.000150921,0.0001645199,0.0003887871,0.0002325666,0.0004294571,0.0004011451],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002269395,"about_ca_system_score_gemma":0.0001796797,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006962589,"about_ca_topic_score_gemma":0.0007325219,"domain_scores_codex":[0.9997087,0.00004830763,0.0000231396,0.00006345317,0.00006051748,0.00009582833],"domain_scores_gemma":[0.9997085,0.00007861211,0.0000664847,0.00002671573,0.00006878474,0.00005089127],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007832157,0.00002530875,0.002331969,0.00003702254,0.000006127896,0.0001638885,0.00004949087,0.00009614169,0.9937783,0.0005790662,0.00009482733,0.002759422],"study_design_scores_gemma":[0.00001912825,0.0002157983,0.03295818,0.00001871623,0.00003160448,0.001395517,0.0002787401,0.002820814,0.9552842,0.0004043344,0.006556983,0.00001592067],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9835295,0.002420934,0.008332001,0.0001025957,0.00002634058,0.00005521215,0.0003203589,0.0000967419,0.005116214],"genre_scores_gemma":[0.9965927,0.0006571235,0.001129107,0.00003601895,0.000007695002,0.00002316134,0.0001732906,0.00001149098,0.001369302],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001028541,"threshold_uncertainty_score":0.003440797,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006181227438251438,"score_gpt":0.2298042560453132,"score_spread":0.2236230286070618,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}