{"id":"W3192670554","doi":"10.1021/acsnano.1c04510","title":"Specific Endothelial Cells Govern Nanoparticle Entry into Solid Tumors","year":2021,"lang":"en","type":"article","venue":"ACS Nano","topic":"Extracellular vesicles in disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":127,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada Research Chairs; University of Toronto","funders":"Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs; Canadian Cancer Society","keywords":"Tumor microenvironment; Nanoparticle; Endothelial stem cell; Cancer research; Tumor cells; Cell biology; Chemistry; Nanotechnology; Materials science; Biophysics; Medicine; Biology; In vitro; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001029324,0.0001702296,0.0001458725,0.00001616956,0.00009312754,0.00005145669,0.0002595767,0.0001117615,0.0001842853],"category_scores_gemma":[0.00007629007,0.0001837517,0.0001176441,0.0001115045,0.00009553429,0.000006237921,0.000253285,0.00008186814,0.000365637],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002914039,"about_ca_system_score_gemma":0.0001492405,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000006450146,"about_ca_topic_score_gemma":0.000009654786,"domain_scores_codex":[0.998676,0.00008047317,0.0002438327,0.0004588891,0.0001984327,0.0003423449],"domain_scores_gemma":[0.9990087,0.00001394353,0.00007183566,0.0006611655,0.00008056641,0.0001637944],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005633107,0.0001746308,0.0005977522,0.00001571139,0.00002881171,0.00014094,0.00005766185,0.0000278938,0.9884368,0.00014143,0.008735658,0.001586375],"study_design_scores_gemma":[0.000534512,0.0000619794,0.0001410019,0.00001098157,0.00001353489,0.00002451129,0.0000751504,0.000009361652,0.8884245,0.0001858757,0.1103182,0.0002003272],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9934172,0.002852174,0.0002238467,0.0001461015,0.000394082,0.0001013174,0.00005072224,0.00002456638,0.002789977],"genre_scores_gemma":[0.9920426,0.0003509769,0.001007145,0.0004148924,0.0004766135,0.00001237833,0.00008279424,0.00004030243,0.005572313],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1015826,"threshold_uncertainty_score":0.7493176,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006181227438251438,"score_gpt":0.2298042560453132,"score_spread":0.2236230286070618,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}