{"id":"W3192681119","doi":"10.3389/fnut.2021.667203","title":"The Induction of Alpha-1 Antitrypsin by Vitamin D in Human T Cells Is TGF-β Dependent: A Proposed Anti-inflammatory Role in Airway Disease","year":2021,"lang":"en","type":"article","venue":"Frontiers in Nutrition","topic":"Vitamin D Research Studies","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Medical Research Council; King's College London; NIHR Leicester Biomedical Research Centre; Imperial College London; National Institute for Health and Care Research; Asthma and Lung UK; York University","keywords":"CD8; Vitamin D and neurology; vitamin D deficiency; Cytotoxic T cell; Immune system; Internal medicine; Vitamin; Endocrinology; Calcitriol receptor; Biology; Transforming growth factor; Downregulation and upregulation; Autocrine signalling; Vitamin D-binding protein; Immunology; In vitro; Medicine; Receptor; Biochemistry; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004969428,0.0001659466,0.0003830043,0.0004105194,0.000102963,0.00002446958,0.0001275344,0.0001295217,0.00001569626],"category_scores_gemma":[0.0001755413,0.0001472964,0.00007924849,0.0005938465,0.0002241294,0.0001815221,0.00008143558,0.0004212632,0.000003178182],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003727344,"about_ca_system_score_gemma":0.0001398315,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008287394,"about_ca_topic_score_gemma":0.000149867,"domain_scores_codex":[0.9979639,0.0002601585,0.0005015217,0.000373462,0.0005161957,0.0003847309],"domain_scores_gemma":[0.9992968,0.00004117784,0.0001063332,0.0003289491,0.0001300675,0.00009670827],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004137318,0.00270049,0.3926606,0.00222009,0.00007261718,0.000489188,0.001162591,0.00001140741,0.5462993,0.00003549808,0.04975507,0.00417944],"study_design_scores_gemma":[0.01102758,0.000246182,0.3066079,0.00288327,0.00005307429,0.000008261884,0.009052888,0.0006919228,0.664566,0.001495394,0.003040224,0.0003273104],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9834421,0.01370603,0.00007175864,0.001242189,0.0002977553,0.001014002,0.00004706911,0.00001787293,0.0001612048],"genre_scores_gemma":[0.9914256,0.007271525,0.0004469414,0.00004234045,0.00007111012,0.0001174714,0.00008458333,0.00002313335,0.000517306],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1182667,"threshold_uncertainty_score":0.6006573,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006750409514274119,"score_gpt":0.2529382096295962,"score_spread":0.2461878001153221,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}