{"id":"W3192736776","doi":"10.1136/jitc-2021-002863","title":"First-in-human phase I/Ib open-label dose-escalation study of GWN323 (anti-GITR) as a single agent and in combination with spartalizumab (anti-PD-1) in patients with advanced solid tumors and lymphomas","year":2021,"lang":"en","type":"article","venue":"Journal for ImmunoTherapy of Cancer","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":46,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"National Center for Advancing Translational Sciences; National Cancer Institute; Novartis","keywords":"Medicine; Tolerability; Adverse effect; Pharmacokinetics; Pharmacodynamics; Internal medicine; Pharmacology; Toxicity; Oncology; Gastroenterology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002474611,0.0001568112,0.0005622052,0.0002521908,0.00009301818,0.00004092596,0.00008750438,0.00004036378,0.00004403818],"category_scores_gemma":[0.00001925741,0.0001158238,0.00002391849,0.0002964415,0.00008676216,0.0002482539,0.00003499725,0.0001601761,7.862594e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001562575,"about_ca_system_score_gemma":0.0001897267,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000763336,"about_ca_topic_score_gemma":0.002195528,"domain_scores_codex":[0.9985306,0.00006503141,0.000552332,0.0002156359,0.0004141042,0.00022229],"domain_scores_gemma":[0.9991741,0.00005647138,0.0003014118,0.0001172591,0.0002854255,0.00006532422],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0276846,0.01216575,0.9067755,0.000238334,0.0002459605,0.00009257409,0.002915851,0.0003328734,0.02418888,0.00004186798,0.000009710887,0.02530811],"study_design_scores_gemma":[0.101464,0.01080757,0.8786379,0.001339719,0.00002559636,0.00003231455,0.0006284361,0.0003375819,0.006274282,0.0001074425,0.0002042858,0.0001409426],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9967623,0.001648989,0.000009078856,0.0003116702,0.00004403873,0.001158126,0.00001312501,0.000002159627,0.0000504528],"genre_scores_gemma":[0.9985268,0.0009522583,0.0002192551,0.00005292687,0.0000137891,0.00005088776,0.00001636787,0.00002470948,0.000143003],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07377937,"threshold_uncertainty_score":0.4723157,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0333281760727157,"score_gpt":0.383287857769983,"score_spread":0.3499596816972673,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}