{"id":"W3192809805","doi":"10.1016/j.jaad.2021.07.040","title":"Efficacy and safety of apremilast in patients with mild-to-moderate plaque psoriasis: Results of a phase 3, multicenter, randomized, double-blind, placebo-controlled trial","year":2021,"lang":"en","type":"article","venue":"Journal of the American Academy of Dermatology","topic":"Psoriasis: Treatment and Pathogenesis","field":"Immunology and Microbiology","cited_by":55,"is_retracted":false,"has_abstract":false,"ca_institutions":"SKiN Health; Bellus Health (Canada); Queen's University; University of British Columbia; Probity Medical Research","funders":"UCB; Celgene; Boehringer Ingelheim; Eli Lilly and Company; Amgen","keywords":"Apremilast; Medicine; Psoriasis; Psoriasis Area and Severity Index; Placebo; Clinical endpoint; Adverse effect; Body surface area; Internal medicine; Dermatology Life Quality Index; Nausea; Randomized controlled trial; Dermatology; Psoriatic arthritis; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002188672,0.001591823,0.004209621,0.0003848341,0.0006085638,0.001134813,0.0008157355,0.002309341,0.004147321],"category_scores_gemma":[0.001935952,0.0007184312,0.002329744,0.0003942664,0.001161684,0.001313805,0.000295109,0.00303694,0.0007050682],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004081676,"about_ca_system_score_gemma":0.0007548432,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004021236,"about_ca_topic_score_gemma":0.0007792892,"domain_scores_codex":[0.9992871,0.0003870431,0.00005639304,0.0001188583,0.00006791467,0.00008281196],"domain_scores_gemma":[0.998899,0.0004045764,0.0002607355,0.00007343618,0.00006774232,0.0002944785],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9781916,0.003809032,0.0005823913,0.0007497329,0.0009504312,0.00004993812,0.00004444279,0.000177197,0.003069689,0.00006307336,0.0005414513,0.0117709],"study_design_scores_gemma":[0.9520052,0.044294,0.002231186,0.00002864498,0.0004567326,0.00004789142,0.00001672698,0.0002162953,0.0002654201,0.00009708983,0.0003251541,0.00001550601],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9756776,0.01635712,0.0008886995,0.0009940797,0.0005788026,0.00234373,0.0008754762,0.0001942479,0.002090174],"genre_scores_gemma":[0.9873738,0.00495807,0.001414502,0.001402263,0.0006430544,0.001661433,0.0008121034,0.00003592314,0.001698982],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004209621,"threshold_uncertainty_score":0.01387417,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01698856682254869,"score_gpt":0.2859902605222075,"score_spread":0.2690016936996588,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}