{"id":"W3192923696","doi":"10.1016/j.cmet.2021.07.015","title":"Exercise-induced angiogenesis is dependent on metabolically primed ATF3/4+ endothelial cells","year":2021,"lang":"en","type":"article","venue":"Cell Metabolism","topic":"Angiogenesis and VEGF in Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":83,"is_retracted":false,"has_abstract":false,"ca_institutions":"Ontario Brain Institute; Toronto Western Hospital; University of Toronto; University Health Network","funders":"H2020 European Research Council; National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Institute on Aging; Novartis Stiftung für Medizinisch-Biologische Forschung; Functional Genomics Center Zurich; Novartis Foundation; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; European Research Council; Consejo Nacional de Ciencia y Tecnología; U.S. Department of Veterans Affairs","keywords":"Angiogenesis; ATF3; Cell biology; Skeletal muscle; Biology; In vivo; Glycolysis; Chemistry; Metabolism; Biochemistry; Endocrinology; Cancer research; Gene expression; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001914039,0.0003784569,0.000431247,0.0002148945,0.0002630529,0.0003558984,0.0002373518,0.0003363967,0.003414348],"category_scores_gemma":[0.0001381693,0.0002323184,0.0005429439,0.0001369503,0.000281522,0.0003137594,0.0002977066,0.0007330148,0.0004893587],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002289516,"about_ca_system_score_gemma":0.0002534602,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005714069,"about_ca_topic_score_gemma":0.0008258978,"domain_scores_codex":[0.9998227,0.00002440718,0.000009633863,0.00004221444,0.00002790318,0.0000732192],"domain_scores_gemma":[0.9998846,0.00001024762,0.00002554764,0.00001988727,0.00001354779,0.00004609816],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002214494,0.000126332,0.0006142631,0.0000842163,0.00001706568,0.0001406159,0.00001904086,0.00007941142,0.9920022,0.0002307675,0.0002089387,0.004262692],"study_design_scores_gemma":[0.0002982918,0.001594341,0.1435686,0.00005540072,0.0001151888,0.000847939,0.000265579,0.002369269,0.8427293,0.0006821307,0.007444805,0.00002915442],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9854455,0.003345247,0.005796641,0.0006027875,0.0002948898,0.00006376643,0.0007680173,0.0001748876,0.003508279],"genre_scores_gemma":[0.9905778,0.00102508,0.001996362,0.0001447351,0.00009632629,0.0001107112,0.0004530165,0.00004185335,0.005554176],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003414348,"threshold_uncertainty_score":0.01142216,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01319430531376295,"score_gpt":0.2444677054240434,"score_spread":0.2312734001102804,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}