{"id":"W3192943827","doi":"10.1002/jcph.1951","title":"Physiologically Based Pharmacokinetic Modeling to Assess the Impact of CYP2D6‐Mediated Drug‐Drug Interactions on Tramadol and O‐Desmethyltramadol Exposures via Allosteric and Competitive Inhibition","year":2021,"lang":"en","type":"article","venue":"The Journal of Clinical Pharmacology","topic":"Veterinary Pharmacology and Anesthesia","field":"Veterinary","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"","keywords":"Tramadol; Quinidine; Pharmacology; CYP2D6; Pharmacokinetics; Drug interaction; Active metabolite; Chemistry; Oral administration; Propoxyphene; Drug; Medicine; Analgesic; Cytochrome P450; Metabolism; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005045718,0.0007850302,0.0008621567,0.000305521,0.0002383617,0.0008572445,0.0008000138,0.0009875708,0.002295214],"category_scores_gemma":[0.001463328,0.0003683915,0.001390746,0.0003287215,0.0002092535,0.0004975771,0.0003987531,0.001372931,0.0007973474],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006806384,"about_ca_system_score_gemma":0.001286066,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.008751119,"about_ca_topic_score_gemma":0.003640401,"domain_scores_codex":[0.9997095,0.00008708567,0.00001899835,0.00004926346,0.0001025432,0.000032626],"domain_scores_gemma":[0.9994645,0.0003189258,0.00007724528,0.00002755243,0.0001006347,0.00001114626],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.0001871133,0.0001842087,0.003067403,0.0002945763,0.0001592473,0.000238389,0.00007665497,0.9582943,0.01955279,0.004070583,0.001102202,0.01277255],"study_design_scores_gemma":[0.00002263325,0.0001525547,0.0008253608,0.000009269887,0.00004933425,0.00008479851,0.00001102436,0.9928144,0.003036663,0.0005940376,0.002384335,0.00001561418],"study_design_candidate":"simulation_or_modeling","study_design_consensus":"simulation_or_modeling","genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.3960385,0.004030434,0.5642352,0.0009935293,0.0001806887,0.0006991819,0.004090369,0.001470628,0.0282616],"genre_scores_gemma":[0.9515701,0.002171635,0.0366706,0.0002645159,0.00003930122,0.0007813427,0.001493262,0.0001377911,0.006871454],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.008751119,"threshold_uncertainty_score":0.01740038,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1831215674548552,"score_gpt":0.4810299608556376,"score_spread":0.2979083934007824,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}