{"id":"W3193030331","doi":"10.3390/ijms22158240","title":"Direct Measurement of the Affinity between tBid and Bax in a Mitochondria-Like Membrane","year":2021,"lang":"en","type":"article","venue":"International Journal of Molecular Sciences","topic":"Cell death mechanisms and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Bacterial outer membrane; Chemistry; Mitochondrion; Transmembrane protein; Membrane protein; Biophysics; Bcl-2 family; Lipid bilayer; Membrane; Nanodisc; Activator (genetics); Cell biology; Biology; Biochemistry; Apoptosis; Programmed cell death; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004714835,0.0003268509,0.0003889986,0.000504587,0.000580095,0.0005573515,0.00061348,0.0006271059,0.00154326],"category_scores_gemma":[0.0007132269,0.0002517022,0.0002479867,0.0003139982,0.0005627834,0.00055437,0.0005559484,0.0009497734,0.0005247466],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006709593,"about_ca_system_score_gemma":0.0002363622,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009912329,"about_ca_topic_score_gemma":0.0007652606,"domain_scores_codex":[0.9994683,0.00009480098,0.00002069403,0.0001935815,0.0001443005,0.00007835837],"domain_scores_gemma":[0.9995357,0.0001899906,0.00008631322,0.00004193792,0.00006869621,0.00007738837],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004420268,0.00001568822,0.0007822554,0.00003809528,0.000009286739,0.00002653164,0.00004033695,0.00005523054,0.9981598,0.0001703837,0.00002382253,0.0006344002],"study_design_scores_gemma":[0.000006092813,0.0001136808,0.01109243,0.000009182999,0.00001775215,0.0003032691,0.00008717158,0.003514255,0.9840546,0.000104435,0.0006878058,0.000009389792],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9764882,0.001668137,0.0197847,0.0001747345,0.00002090555,0.00002392987,0.0001246684,0.00008107979,0.001633634],"genre_scores_gemma":[0.9861088,0.0006927176,0.01124139,0.0001278614,0.00001319352,0.0000364023,0.0002383109,0.00001602878,0.001525289],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00154326,"threshold_uncertainty_score":0.005162716,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01794131229260157,"score_gpt":0.2591440307144237,"score_spread":0.2412027184218221,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}