{"id":"W3193036633","doi":"10.1177/13524585211034826","title":"White matter microstructural differences in children and genetic risk for multiple sclerosis: A population-based study","year":2021,"lang":"en","type":"article","venue":"Multiple Sclerosis Journal","topic":"Multiple Sclerosis Research Studies","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institutes of Health; Olav Thon Stiftelsen; IXICO; H. Lundbeck A/S; Genentech; Vlaamse regering; Innovative Medicines Initiative; University College London Hospitals NHS Foundation Trust; Vetenskapsrådet; Eisai; National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; Fonds Wetenschappelijk Onderzoek; Servier; Stichting MS Research; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; National Research Foundation; UK Dementia Research Institute; European Federation of Pharmaceutical Industries and Associations; National Institute on Aging; National Institute for Health and Care Research; Northern California Institute for Research and Education; Pfizer; Biogen; BioClinica; Alzheimer's Drug Discovery Foundation; ZonMw; Universiteit Antwerpen; Alzheimer's Association; Stiftelsen för Gamla Tjänarinnor; Hjärnfonden; European Commission; Familjen Erling-Perssons Stiftelse; University of Southern California; Novartis Pharmaceuticals Corporation; Eusko Jaurlaritza; U.S. Department of Defense; Eli Lilly and Company; Bristol-Myers Squibb; F. Hoffmann-La Roche; Alzheimer's Disease Neuroimaging Initiative; Meso Scale Diagnostics; Foundation for the National Institutes of Health","keywords":"Fractional anisotropy; Corpus callosum; White matter; Diffusion MRI; Multiple sclerosis; Population; Medicine; Magnetic resonance imaging; Pathology; Radiology; Psychiatry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007450617,0.00065078,0.0005961319,0.001624597,0.0007072452,0.000719422,0.0004513184,0.0008952228,0.001756491],"category_scores_gemma":[0.002386896,0.0005790245,0.0005844496,0.001801244,0.0006056536,0.0006682933,0.0005712594,0.0006730442,0.000329174],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004042785,"about_ca_system_score_gemma":0.0003077915,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.008357398,"about_ca_topic_score_gemma":0.006574108,"domain_scores_codex":[0.9994006,0.000120545,0.00006285156,0.0002247888,0.0001260485,0.00006514259],"domain_scores_gemma":[0.9987807,0.000234735,0.0005888932,0.0001195576,0.0001126037,0.000163572],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00006520043,0.00003339067,0.9986733,0.000006751302,0.00007156033,0.0001658445,0.0001785931,0.00002906773,0.0002403565,0.00001366683,0.00004518051,0.0004770582],"study_design_scores_gemma":[0.000005726743,0.0000816776,0.9990692,0.000003903486,0.00003341315,0.0004958227,0.0001458095,0.00004590944,0.00003496682,0.00001235662,0.00006835727,0.000003016233],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9995011,0.00006612852,0.0000496099,0.00001553893,0.000001785918,0.000006178402,0.0002388911,0.000003091215,0.0001177099],"genre_scores_gemma":[0.9992816,0.0001051577,0.0001346622,0.00001547023,0.000006417196,0.00001545423,0.0003449499,0.000003930205,0.00009246867],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008357398,"threshold_uncertainty_score":0.01661754,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06096524518228003,"score_gpt":0.282307210293065,"score_spread":0.221341965110785,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}