{"id":"W3193107269","doi":"10.1371/journal.pgen.1009529","title":"Connection of core and tail Mediator modules restrains transcription from TFIID-dependent promoters","year":2021,"lang":"en","type":"article","venue":"PLoS Genetics","topic":"Genomics and Chromatin Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Montreal Clinical Research Institute","funders":"National Institute of General Medical Sciences; Fonds de recherche du Québec – Nature et technologies; Canadian Institutes of Health Research; National Institutes of Health","keywords":"Biology; TAF1; Transcription factor II D; Mediator; Coactivator; Cell biology; Genetics; Transcription factor II A; Protein subunit; Promoter; Transcription (linguistics); Transcription factor; General transcription factor; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001296024,0.0002192867,0.0002529161,0.0001569749,0.0001294295,0.0003140752,0.0002204237,0.0001647665,0.0007245654],"category_scores_gemma":[0.0001465455,0.0002247363,0.0001897002,0.00009485202,0.0002776151,0.0001369812,0.0005008316,0.0004064747,0.0003109933],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002726268,"about_ca_system_score_gemma":0.0001800951,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002703088,"about_ca_topic_score_gemma":0.0005528669,"domain_scores_codex":[0.9998629,0.00001182966,0.00001278874,0.00004019865,0.00003132555,0.0000409664],"domain_scores_gemma":[0.9997836,0.00003619463,0.00006211147,0.00003814473,0.0000161807,0.00006381281],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005090281,0.000003651463,0.0002177539,0.000006252349,0.00000140871,0.0000116607,0.000003394762,0.00001583844,0.9993414,0.00003321714,0.000003201654,0.0003113314],"study_design_scores_gemma":[0.00000745793,0.00006218383,0.0052575,0.000002000616,0.000006653747,0.0001241422,0.00001344248,0.0004485343,0.9934828,0.0000334298,0.0005598264,0.000002086443],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978638,0.0002438338,0.00146435,0.00001988716,0.000006724427,0.000003356202,0.00005044129,0.00004070002,0.0003069131],"genre_scores_gemma":[0.9982509,0.00006882483,0.000701545,0.00001334352,0.000002950555,0.000004622974,0.0001771234,0.00001731572,0.0007633137],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007245654,"threshold_uncertainty_score":0.002423882,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01606491624362167,"score_gpt":0.2161925563061645,"score_spread":0.2001276400625428,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}