{"id":"W3193107269","doi":"10.1371/journal.pgen.1009529","title":"Connection of core and tail Mediator modules restrains transcription from TFIID-dependent promoters","year":2021,"lang":"en","type":"article","venue":"PLoS Genetics","topic":"Genomics and Chromatin Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Montreal Clinical Research Institute","funders":"National Institute of General Medical Sciences; Fonds de recherche du Québec – Nature et technologies; Canadian Institutes of Health Research; National Institutes of Health","keywords":"Biology; TAF1; Transcription factor II D; Mediator; Coactivator; Cell biology; Genetics; Transcription factor II A; Protein subunit; Promoter; Transcription (linguistics); Transcription factor; General transcription factor; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00004597723,0.0001154178,0.0001344,0.00001891506,0.00003775757,0.00001651393,0.00007936001,0.0001443429,0.00001773528],"category_scores_gemma":[0.00003217728,0.0001258035,0.00004625365,0.00003643539,0.00006111734,0.000001760952,0.0000500217,0.00005687291,0.000001151679],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001066995,"about_ca_system_score_gemma":0.00005940863,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00000721326,"about_ca_topic_score_gemma":0.0002058278,"domain_scores_codex":[0.9992354,0.00003044693,0.00020739,0.0002784094,0.0001220534,0.0001263346],"domain_scores_gemma":[0.9994904,0.000007718721,0.00008091191,0.0002508022,0.0001038944,0.00006624521],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001799622,0.00008528513,0.002940932,0.00003822359,0.00007618687,0.000003346631,0.0001763051,0.0001525462,0.9956395,0.00004098403,0.00003509038,0.0007935719],"study_design_scores_gemma":[0.0005281602,0.0001735818,0.003909966,0.00001857138,0.00006932749,0.000009493834,0.0003549885,0.006789517,0.987097,0.0006005828,0.0002953062,0.0001534808],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9972193,0.001521621,0.0006193226,0.00007926506,0.0001337112,0.0001167522,0.0002209272,0.000006893873,0.00008225226],"genre_scores_gemma":[0.9956201,0.001096301,0.00259855,0.00004190147,0.000115993,0.000007661079,0.0004362639,0.00002163232,0.00006154717],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008542508,"threshold_uncertainty_score":0.5130117,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01606491624362167,"score_gpt":0.2161925563061645,"score_spread":0.2001276400625428,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}