{"id":"W3193127945","doi":"10.1002/9781119772767.ch5","title":"The Vasoconstrictor Assay ( <scp>VCA</scp> ): Then and Now","year":2021,"lang":"en","type":"other","venue":"","topic":"Contact Dermatitis and Allergies","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Potency; Bioequivalence; Corticosteroid; Medicine; Pharmacology; Product (mathematics); Biosimilar; Chemistry; Internal medicine; Pharmacokinetics; Biochemistry; In vitro; Mathematics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004868535,0.001357161,0.001059558,0.003111156,0.0006972383,0.002606544,0.001245861,0.002268064,0.01423729],"category_scores_gemma":[0.004417498,0.000575453,0.0009491448,0.001738215,0.001626267,0.00171049,0.001339155,0.003298604,0.01237295],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009956567,"about_ca_system_score_gemma":0.001998995,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002893371,"about_ca_topic_score_gemma":0.005198822,"domain_scores_codex":[0.9910612,0.00189238,0.0005852887,0.001149514,0.005045968,0.0002658073],"domain_scores_gemma":[0.9967229,0.001114495,0.0005079972,0.0002951083,0.00118637,0.0001731972],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0008756104,0.0002540149,0.00364919,0.004011757,0.0001346404,0.0006686946,0.0002426917,0.0004383553,0.2689297,0.02466825,0.1382199,0.5579072],"study_design_scores_gemma":[0.00007480599,0.0008568664,0.005408427,0.0006412053,0.00008961459,0.002677779,0.0001227769,0.0008922144,0.2039652,0.002606196,0.7825544,0.0001105267],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"other","genre_scores_codex":[0.03584522,0.3318288,0.3072226,0.01442576,0.01548324,0.003005868,0.02035595,0.01311804,0.2587145],"genre_scores_gemma":[0.1798607,0.1602911,0.2749612,0.01935776,0.003974376,0.003255792,0.02180761,0.002769084,0.3337224],"genre_candidate":"other","genre_consensus":null,"teacher_disagreement_score":0.01423729,"threshold_uncertainty_score":0.04762846,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01061530613351564,"score_gpt":0.2388454899038777,"score_spread":0.2282301837703621,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}