{"id":"W3193129090","doi":"10.32607/actanaturae.11031","title":"Parkinson’s Disease Associated with GBA Gene Mutations: Molecular Aspects and Potential Treatment Approaches","year":2021,"lang":"en","type":"article","venue":"Acta Naturae","topic":"Lysosomal Storage Disorders Research","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Montreal Neurological Institute and Hospital","funders":"","keywords":"Glucocerebrosidase; Parkinson's disease; Disease; Pathogenesis; Gene; Genetics; Biology; Bioinformatics; Medicine; Immunology; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005509813,0.0001610281,0.00022221,0.00007312953,0.0001033016,0.00005629331,0.00004568553,0.00008145338,0.0000603316],"category_scores_gemma":[0.0004237921,0.000122411,0.00007151769,0.0002964193,0.00008163304,0.00007710174,0.00004198724,0.0001667744,0.000006013398],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001855702,"about_ca_system_score_gemma":0.0003472161,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002472156,"about_ca_topic_score_gemma":0.00002593563,"domain_scores_codex":[0.9987343,0.00008659314,0.0001129165,0.0003775676,0.0004184141,0.0002702244],"domain_scores_gemma":[0.9992726,0.0000542147,0.00004220442,0.0002221454,0.0001401669,0.0002686005],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.008330762,0.01906468,0.2737807,0.0009627279,0.01595347,0.1514751,0.005249919,0.0004347552,0.3250233,0.00206571,0.001741175,0.1959178],"study_design_scores_gemma":[0.0101475,0.0007613175,0.9429104,0.000178056,0.001114339,0.0003408892,0.0007675477,0.002099158,0.03951188,0.0003616194,0.001341512,0.0004657899],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9872953,0.008716897,0.00005618558,0.002711113,0.00003022185,0.0004221109,0.00002906258,0.00005244887,0.0006866831],"genre_scores_gemma":[0.9978576,0.0001918966,0.0003369366,0.0001809083,0.00004055332,0.00005732898,0.00058525,0.00003032694,0.0007191674],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6691297,"threshold_uncertainty_score":0.4991776,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0232283192887137,"score_gpt":0.2594295078975451,"score_spread":0.2362011886088314,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}