{"id":"W3193129090","doi":"10.32607/actanaturae.11031","title":"Parkinson’s Disease Associated with GBA Gene Mutations: Molecular Aspects and Potential Treatment Approaches","year":2021,"lang":"en","type":"article","venue":"Acta Naturae","topic":"Lysosomal Storage Disorders Research","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Montreal Neurological Institute and Hospital","funders":"","keywords":"Glucocerebrosidase; Parkinson's disease; Disease; Pathogenesis; Gene; Genetics; Biology; Bioinformatics; Medicine; Immunology; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004885927,0.0006745356,0.00109719,0.001237741,0.0003302509,0.0009288968,0.0007286855,0.001460839,0.001887854],"category_scores_gemma":[0.0003087513,0.0002138227,0.0009365572,0.0005692561,0.0004827393,0.0008101155,0.0006775516,0.001638208,0.0004752503],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005579003,"about_ca_system_score_gemma":0.000550376,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005577089,"about_ca_topic_score_gemma":0.001196206,"domain_scores_codex":[0.9998554,0.00004238533,0.00001936386,0.00002474702,0.00002824296,0.00002988356],"domain_scores_gemma":[0.99991,0.00002895611,0.00002181746,0.000006453228,0.00001577388,0.00001709098],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.002260332,0.002226767,0.003557942,0.00691629,0.0005668308,0.006377719,0.0002406886,0.001948123,0.02642327,0.01716013,0.009111451,0.9232105],"study_design_scores_gemma":[0.003497139,0.01151578,0.04140084,0.01321166,0.00354904,0.05772087,0.001712335,0.007845084,0.02931345,0.07743452,0.7524336,0.0003657158],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.01387788,0.9737447,0.002297143,0.004862308,0.0003515464,0.0000646383,0.00007005463,0.00004415876,0.004687604],"genre_scores_gemma":[0.1085703,0.8788049,0.006327988,0.001716482,0.001390121,0.0001932767,0.0002509826,0.00001359137,0.002732485],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.001887854,"threshold_uncertainty_score":0.006315529,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0232283192887137,"score_gpt":0.2594295078975451,"score_spread":0.2362011886088314,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}