{"id":"W3193302010","doi":"10.1172/jci.insight.151621","title":"Combinatorial transcription factor profiles predict mature and functional human islet α and β cells","year":2021,"lang":"en","type":"article","venue":"JCI Insight","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":46,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of General Medical Sciences; Juvenile Diabetes Research Foundation United States of America; National Cancer Institute; National Institutes of Health; U.S. Department of Veterans Affairs; Leona M. and Harry B. Helmsley Charitable Trust; Vanderbilt Diabetes Research and Training Center, Vanderbilt University Medical Center; Vanderbilt University","keywords":"Islet; Biology; Transcription factor; Cell biology; Gene expression; Gene; Insulin; Endocrinology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001357546,0.0001490959,0.0002571722,0.0003764188,0.0001207871,0.0005167311,0.00008025918,0.000209394,0.001161657],"category_scores_gemma":[0.0003707727,0.0001181499,0.0002083474,0.0003429899,0.0001070404,0.000152301,0.0001814738,0.0002032263,0.0005036708],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001321009,"about_ca_system_score_gemma":0.0000847298,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005926269,"about_ca_topic_score_gemma":0.001015022,"domain_scores_codex":[0.9998957,0.000005386482,0.000007603841,0.00005179688,0.00001956415,0.00001995851],"domain_scores_gemma":[0.9998171,0.00005183273,0.00003882595,0.00001963279,0.00003285213,0.00003970145],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002828063,0.00001256926,0.04688956,0.00003397229,0.00002208302,0.0000646139,0.00009000213,0.0002892849,0.946544,0.00008167994,0.0001047905,0.005584694],"study_design_scores_gemma":[0.00002479876,0.0002510726,0.6805254,0.00001813913,0.0001359487,0.001613597,0.0003154248,0.005996138,0.3061927,0.000532066,0.004364033,0.00003070567],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9925202,0.000529098,0.004639297,0.00001955216,0.000005501407,0.00001121876,0.001506432,0.00006404439,0.0007047403],"genre_scores_gemma":[0.9936587,0.0002025382,0.003419533,0.00004377674,0.000007859852,0.00002096688,0.002089661,0.00003597804,0.0005210437],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001161657,"threshold_uncertainty_score":0.003886163,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01840641457388466,"score_gpt":0.2296730524766269,"score_spread":0.2112666379027423,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}