{"id":"W3193302010","doi":"10.1172/jci.insight.151621","title":"Combinatorial transcription factor profiles predict mature and functional human islet α and β cells","year":2021,"lang":"en","type":"article","venue":"JCI Insight","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":46,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of General Medical Sciences; Juvenile Diabetes Research Foundation United States of America; National Cancer Institute; National Institutes of Health; U.S. Department of Veterans Affairs; Leona M. and Harry B. Helmsley Charitable Trust; Vanderbilt Diabetes Research and Training Center, Vanderbilt University Medical Center; Vanderbilt University","keywords":"Islet; Biology; Transcription factor; Cell biology; Gene expression; Gene; Insulin; Endocrinology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00003839927,0.0001161548,0.0002058687,0.00005163877,0.0001042001,0.00003732706,0.00001208496,0.0001316087,0.0007924724],"category_scores_gemma":[0.00003585562,0.00009471003,0.00003948494,0.0000827128,0.00006373601,0.00009186594,0.00001330598,0.000159587,0.00001145819],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002039705,"about_ca_system_score_gemma":0.00005230906,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000004810233,"about_ca_topic_score_gemma":0.000001034171,"domain_scores_codex":[0.9992903,0.00003419437,0.0001429723,0.0002250558,0.0001880772,0.0001193891],"domain_scores_gemma":[0.9996087,0.00004056063,0.00003073995,0.0001141274,0.00008379773,0.0001220623],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000132904,0.0001828932,0.01039927,0.0002182216,0.00007929806,0.00002701825,0.0004218352,1.422083e-7,0.9706504,0.005028666,0.01253564,0.0003237023],"study_design_scores_gemma":[0.007589047,0.0006181402,0.3029156,0.0002017909,0.0002638272,0.00008795233,0.0003064413,0.00009629917,0.5257518,0.001757659,0.160125,0.0002865327],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9876485,0.001058421,0.00003249334,0.0005222652,0.001043199,0.0001778313,0.00004009481,0.00006446527,0.009412772],"genre_scores_gemma":[0.9958899,0.00008346739,0.00009998426,0.0004893001,0.0005334275,0.00001399015,0.0001576051,0.00001280272,0.002719513],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4448987,"threshold_uncertainty_score":0.8677017,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01840641457388466,"score_gpt":0.2296730524766269,"score_spread":0.2112666379027423,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}