{"id":"W3193318723","doi":"10.1158/2159-8290.cd-21-0236","title":"Microbiota-Centered Interventions: The Next Breakthrough in Immuno-Oncology?","year":2021,"lang":"en","type":"review","venue":"Cancer Discovery","topic":"Gut microbiota and health","field":"Biochemistry, Genetics and Molecular Biology","cited_by":163,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier de l’Université de Montréal","funders":"Agence Nationale de la Recherche","keywords":"Dysbiosis; Immune system; Fecal bacteriotherapy; Immunotherapy; Antibiotics; Cancer immunotherapy; Transplantation; Immunology; Cancer; Medicine; Gut flora; Psychological intervention; Biology; Internal medicine; Microbiology; Clostridium difficile","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002458805,0.0003980288,0.001076463,0.00007040802,0.00009953293,0.0001356448,0.0005614571,0.0005157282,0.000116095],"category_scores_gemma":[0.0000309276,0.0002857441,0.001078537,0.0002470168,0.0001530627,0.00001335678,0.0004223832,0.0004352072,0.00002370234],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003484387,"about_ca_system_score_gemma":0.001666398,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000233987,"about_ca_topic_score_gemma":0.00131814,"domain_scores_codex":[0.9977254,0.000378496,0.0007560047,0.0006429809,0.00006525356,0.0004318728],"domain_scores_gemma":[0.9987383,0.00003344633,0.0003754523,0.0007560658,0.00004978585,0.00004694428],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00003873212,0.0004267144,0.00003538142,0.01640967,0.0008133008,0.00003931316,0.0001227819,0.000002748196,0.007118457,0.0001044248,0.05852384,0.9163646],"study_design_scores_gemma":[0.0003342507,0.00006958222,0.00002980412,0.01360036,0.0002592,0.00008335862,0.0001131292,7.694476e-8,0.00007699569,0.000003493674,0.9851356,0.0002941195],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0003630937,0.9966805,0.00003345733,0.0002220721,0.00125323,0.0007009415,0.0004135609,0.00000648315,0.0003266626],"genre_scores_gemma":[0.0001150525,0.9941156,0.00003385804,0.0005237237,0.0004719233,0.0003132615,0.001540737,0.00005958934,0.002826273],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9266118,"threshold_uncertainty_score":0.9999595,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1201179876233159,"score_gpt":0.4250358951435871,"score_spread":0.3049179075202713,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}