{"id":"W3193354979","doi":"10.3389/fpsyt.2021.701729","title":"A Phase II Randomized, Double-Blind, Placebo-Controlled Study of the Efficacy, Safety, and Tolerability of Arbaclofen Administered for the Treatment of Social Function in Children and Adolescents With Autism Spectrum Disorders: Study Protocol for AIMS-2-TRIALS-CT1","year":2021,"lang":"en","type":"article","venue":"Frontiers in Psychiatry","topic":"Autism Spectrum Disorder Research","field":"Neuroscience","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"Holland Bloorview Kids Rehabilitation Hospital; University of Toronto","funders":"Horizon 2020; Innovative Medicines Initiative; Medical Research Council; European Federation of Pharmaceutical Industries and Associations; Simons Foundation; European Commission; Autism Speaks","keywords":"Autism; Tolerability; Autism spectrum disorder; Randomized controlled trial; Vineland Adaptive Behavior Scale; Quality of life (healthcare); Psychology; Clinical Global Impression; Clinical psychology; Clinical trial; Placebo; Psychological intervention; Adverse effect; Psychiatry; Medicine; Physical therapy; Internal medicine; Psychotherapist; Alternative medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001812609,0.0003026826,0.001693785,0.0001885938,0.0003095741,0.00003288738,0.0002994329,0.00009137903,0.000005633882],"category_scores_gemma":[0.0002311846,0.0001725396,0.0002712899,0.0005219952,0.0004061103,0.00008373627,0.000118663,0.0001834022,2.805942e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007417578,"about_ca_system_score_gemma":0.0003196815,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001388042,"about_ca_topic_score_gemma":0.001882702,"domain_scores_codex":[0.9957387,0.001504761,0.001287765,0.0006823582,0.0004461945,0.0003402357],"domain_scores_gemma":[0.9981185,0.0005564131,0.0007610743,0.0005015876,0.00001782826,0.00004465562],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.790177,0.03401957,0.1686087,0.0001236779,0.0003170759,2.35832e-7,0.004845825,0.00002524058,0.00001508633,0.0004973686,0.00002035923,0.00134982],"study_design_scores_gemma":[0.8952783,0.01153659,0.08554643,0.00008464772,0.0003990614,0.000001281322,0.002516916,0.0005329207,0.0001502034,0.00379108,0.00001287664,0.0001497065],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6910114,0.00009125622,0.0005738077,0.001639929,0.000335814,0.3062811,0.00004763612,0.000007322344,0.00001166758],"genre_scores_gemma":[0.8954253,0.00001791585,0.0001088189,0.00001055216,0.00003548503,0.1043495,0.000002173575,0.00002612605,0.00002408981],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2044139,"threshold_uncertainty_score":0.7035961,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03296690906180837,"score_gpt":0.3582857180665109,"score_spread":0.3253188090047025,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}