{"id":"W3193401888","doi":"10.1073/pnas.2111257118","title":"Dissecting the role of interprotomer cooperativity in the activation of oligomeric high-temperature requirement A2 protein","year":2021,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Neurological diseases and metabolism","field":"Neuroscience","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; University of Toronto","funders":"National Institute of General Medical Sciences; Canadian Institutes of Health Research","keywords":"PDZ domain; Allosteric regulation; Biophysics; Active site; Protein subunit; Cooperativity; Chemistry; Protein structure; Protease; Proteolysis; Proteostasis; Cooperative binding; Biochemistry; Binding site; Enzyme; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001007789,0.00008036582,0.0001526916,0.00006543873,0.0001555606,0.00002581467,0.0007628677,0.00004317846,0.00001233462],"category_scores_gemma":[0.003225782,0.00003640267,0.0000690938,0.00146009,0.0006625506,0.0003324706,0.000163808,0.0002143217,1.609109e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001002194,"about_ca_system_score_gemma":0.0000416941,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001060987,"about_ca_topic_score_gemma":1.222852e-7,"domain_scores_codex":[0.998202,0.00005757586,0.0003303339,0.0002338088,0.001056299,0.0001200102],"domain_scores_gemma":[0.9989945,0.0002645285,0.0004422948,0.0000186748,0.0002646957,0.00001524972],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002430306,0.0001095676,0.001127044,0.00003201603,0.000001905636,9.383786e-9,0.0002443324,0.00005524143,0.9046772,0.09349141,0.000007566076,0.0002294289],"study_design_scores_gemma":[0.00009024777,0.00004522734,0.0528481,0.00007510954,0.00000461823,0.000001763793,0.0004333891,0.000145384,0.9210145,0.02524838,0.00005750678,0.00003578341],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9949402,0.00006314088,1.986512e-7,0.003398699,0.00001803429,0.000504838,0.0000106905,0.000003294832,0.001060949],"genre_scores_gemma":[0.9993051,0.00001733646,0.00005206669,0.0004925671,0.00003803124,0.0000578769,6.657606e-8,0.000002302353,0.00003466374],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06824303,"threshold_uncertainty_score":0.3861795,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03964193067586393,"score_gpt":0.3092269185732491,"score_spread":0.2695849878973852,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}