{"id":"W3193450770","doi":"10.1371/journal.ppat.1009825","title":"Increased homeostatic cytokines and stability of HIV-infected memory CD4 T-cells identify individuals with suboptimal CD4 T-cell recovery on-ART","year":2021,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier de l’Université de Montréal","funders":"National Institute of Allergy and Infectious Diseases; Eli Lilly and Company; Emory University; Center for AIDS Research, Emory University; National Institutes of Health; Gilead Sciences","keywords":"TIGIT; Homeostasis; Immunology; T cell; Cell; Cd4 t cell; Antiretroviral therapy; Memory T cell; Immune system; Medicine; Viral load; Chemistry; Human immunodeficiency virus (HIV); Biology; Cell biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002779363,0.0003009639,0.0003891048,0.0004838649,0.0002155386,0.0008077379,0.0001980036,0.0003504591,0.00237018],"category_scores_gemma":[0.0006461362,0.0001785998,0.0001716499,0.0002917692,0.0002190152,0.0003265289,0.0003087731,0.0004642064,0.0003311965],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001598883,"about_ca_system_score_gemma":0.0001117449,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003709025,"about_ca_topic_score_gemma":0.000420473,"domain_scores_codex":[0.9997874,0.00004937934,0.00002225298,0.0000557254,0.00002915307,0.00005608768],"domain_scores_gemma":[0.9997445,0.00005302037,0.00008977389,0.00002963717,0.00003602802,0.00004714528],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.004025669,0.0003619561,0.6765295,0.0002207506,0.0001301952,0.00046449,0.0008419536,0.0004868735,0.277002,0.0002242286,0.0003711367,0.03934129],"study_design_scores_gemma":[0.00002978668,0.001267352,0.9640685,0.00003939518,0.0001100756,0.001082864,0.0006904199,0.001009974,0.03010558,0.0002615264,0.001321331,0.00001319084],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9982712,0.0006016028,0.000241862,0.0000177599,0.000004185438,0.00001461186,0.0001672351,0.0000147548,0.0006667611],"genre_scores_gemma":[0.9987872,0.0001121507,0.0002968781,0.00003501555,0.0000106177,0.00002220546,0.0002472684,0.000005244676,0.0004833728],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00237018,"threshold_uncertainty_score":0.007929027,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0155069812657225,"score_gpt":0.2337022319127406,"score_spread":0.2181952506470181,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}