{"id":"W3193450770","doi":"10.1371/journal.ppat.1009825","title":"Increased homeostatic cytokines and stability of HIV-infected memory CD4 T-cells identify individuals with suboptimal CD4 T-cell recovery on-ART","year":2021,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier de l’Université de Montréal","funders":"National Institute of Allergy and Infectious Diseases; Eli Lilly and Company; Emory University; Center for AIDS Research, Emory University; National Institutes of Health; Gilead Sciences","keywords":"TIGIT; Homeostasis; Immunology; T cell; Cell; Cd4 t cell; Antiretroviral therapy; Memory T cell; Immune system; Medicine; Viral load; Chemistry; Human immunodeficiency virus (HIV); Biology; Cell biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0002733248,0.0002743815,0.0005145106,0.0001462551,0.0001434883,0.00002860335,0.0001257427,0.0001497614,0.00127268],"category_scores_gemma":[0.0002078507,0.0002197833,0.0001022142,0.0002604097,0.0003090865,0.00008821757,0.000121944,0.0002716736,0.0007241601],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005352648,"about_ca_system_score_gemma":0.0002927081,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000327377,"about_ca_topic_score_gemma":0.00005961577,"domain_scores_codex":[0.9978614,0.0006290249,0.0003508441,0.0005322198,0.0001407848,0.0004856885],"domain_scores_gemma":[0.9984339,0.0006420161,0.0001458625,0.0005159693,0.0001658926,0.0000963841],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004415787,0.001986282,0.09910128,0.0001784663,0.0005657476,0.0002538345,0.0003371003,0.000003442612,0.8954532,0.00000591155,0.001282964,0.0003901695],"study_design_scores_gemma":[0.003337938,0.0008932718,0.07137097,0.00008228361,0.0002279226,0.00004894181,0.000324873,0.000001884166,0.9230137,0.00002140859,0.000449256,0.0002275327],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9939502,0.0006888933,0.00002037641,0.0001172248,0.00006692464,0.0004887187,0.003341582,0.0000510084,0.001275066],"genre_scores_gemma":[0.9969488,0.0002206827,0.0004945483,0.00006364963,0.00001215581,0.00006066971,0.001655056,0.0000295808,0.0005148069],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02773031,"threshold_uncertainty_score":0.9996403,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0155069812657225,"score_gpt":0.2337022319127406,"score_spread":0.2181952506470181,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}