{"id":"W3193463837","doi":"10.1002/dad2.12240","title":"Identification of plasma proteins relating to brain neurodegeneration and vascular pathology in cognitively normal individuals","year":2021,"lang":"en","type":"article","venue":"Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Chief Scientist Office, Scottish Government Health and Social Care Directorate; National Institutes of Health; UK Dementia Research Institute; Fondation Leducq; Economic and Social Research Council; Rosetrees Trust; European Commission; University of Oxford; Alzheimer Society; UK Research and Innovation; Medical Research Scotland; British Heart Foundation; Scottish Government; Sackler Trust; Dementias Platform UK; Age UK; Horizon 2020 Framework Programme; Scottish Funding Council; Wellcome Trust; National Institute on Aging; TauRx Pharmaceuticals; Medical Research Council; Biogen","keywords":"Neurodegeneration; Hyperintensity; Hippocampal formation; Disease; Pathology; White matter; Vascular dementia; Neuroscience; Psychology; Medicine; Internal medicine; Bioinformatics; Biology; Magnetic resonance imaging; Dementia","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003728258,0.0003309715,0.0002408517,0.0009140579,0.0003211088,0.0004539146,0.0001700849,0.0003210837,0.001374536],"category_scores_gemma":[0.0008303298,0.0001110997,0.0002997652,0.0006672677,0.0002325943,0.0001906273,0.0003177368,0.0002338373,0.0001739464],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002133283,"about_ca_system_score_gemma":0.0001941811,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001458556,"about_ca_topic_score_gemma":0.001595282,"domain_scores_codex":[0.9998434,0.00002525744,0.0000156498,0.00005905114,0.0000321287,0.00002452863],"domain_scores_gemma":[0.9996227,0.00005113037,0.0002235234,0.00002388128,0.00004389972,0.00003485166],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0006187476,0.00006422284,0.9670838,0.00009977602,0.0002344288,0.0003476254,0.0001960952,0.0001065126,0.01857169,0.0001090731,0.0002758448,0.01229209],"study_design_scores_gemma":[0.000007449477,0.000108107,0.9965145,0.000008589879,0.00005506498,0.0006485945,0.0001107791,0.0001506466,0.001917886,0.0001818362,0.0002924915,0.00000408158],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9981453,0.0006826486,0.0002261939,0.00005618536,0.000004635522,0.000004198294,0.0005006338,0.000007165306,0.0003730315],"genre_scores_gemma":[0.9987662,0.0002343299,0.0003522167,0.0000404042,0.000008839404,0.00000569793,0.0003624859,0.000001586295,0.0002281863],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001458556,"threshold_uncertainty_score":0.00459832,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03164072596528755,"score_gpt":0.3377186139028401,"score_spread":0.3060778879375525,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}