{"id":"W3193464565","doi":"10.1016/j.ygcen.2021.113891","title":"Cylindrospermopsin directly disrupts spermatogenesis in isolated male zebrafish testis","year":2021,"lang":"en","type":"article","venue":"General and Comparative Endocrinology","topic":"Reproductive Biology and Fertility","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Calgary","funders":"Natural Sciences and Engineering Research Council of Canada; Conselho Nacional de Desenvolvimento Científico e Tecnológico","keywords":"Biology; Zebrafish; Spermatogenesis; Cylindrospermopsin; Reproductive toxicity; Testosterone (patch); Endocrinology; Internal medicine; Apoptosis; Toxicity; Cell biology; Andrology; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005389922,0.0001915104,0.0005474164,0.00007284569,0.00008174478,0.000008989368,0.00005635097,0.000101638,0.0003522294],"category_scores_gemma":[0.00006074368,0.0001615542,0.00006189146,0.0002313391,0.0002849433,0.00005442759,0.00009965136,0.0002407844,0.00004772064],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000262229,"about_ca_system_score_gemma":0.00007038753,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006801843,"about_ca_topic_score_gemma":0.0001599536,"domain_scores_codex":[0.9984534,0.0002141231,0.0002834026,0.0005998106,0.00006413017,0.0003850907],"domain_scores_gemma":[0.9994001,0.00005944273,0.00004609529,0.0002760168,0.0001215149,0.00009677229],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0009095967,0.0003313597,0.8236547,0.00002207839,0.0001159119,0.001126743,0.0003219578,0.000007731555,0.1693891,0.001137905,0.0004227942,0.002560133],"study_design_scores_gemma":[0.001099135,0.0001726938,0.9167124,0.00001337489,0.00003332215,0.003110962,0.0001021657,0.0003053523,0.0742241,0.0002839882,0.003789162,0.0001533275],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9864533,0.004851474,0.00005873652,0.001546103,0.0002035145,0.0002010918,0.000015035,0.00003896587,0.006631786],"genre_scores_gemma":[0.9944602,0.0002365486,0.0005108028,0.000556525,0.000129209,0.00003215608,0.00006083112,0.000006535829,0.004007146],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09516495,"threshold_uncertainty_score":0.6587991,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04668338379231798,"score_gpt":0.3055214303209878,"score_spread":0.2588380465286698,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}