{"id":"W3193464565","doi":"10.1016/j.ygcen.2021.113891","title":"Cylindrospermopsin directly disrupts spermatogenesis in isolated male zebrafish testis","year":2021,"lang":"en","type":"article","venue":"General and Comparative Endocrinology","topic":"Reproductive Biology and Fertility","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Calgary","funders":"Natural Sciences and Engineering Research Council of Canada; Conselho Nacional de Desenvolvimento Científico e Tecnológico","keywords":"Biology; Zebrafish; Spermatogenesis; Cylindrospermopsin; Reproductive toxicity; Testosterone (patch); Endocrinology; Internal medicine; Apoptosis; Toxicity; Cell biology; Andrology; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002300671,0.0004424464,0.0003175491,0.0006300468,0.0003484699,0.0003170557,0.0004247212,0.0008028751,0.002819116],"category_scores_gemma":[0.0001675398,0.0003983826,0.0005130009,0.0002602874,0.0007665897,0.000308428,0.0003812096,0.001266336,0.0004311232],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001007541,"about_ca_system_score_gemma":0.0008180883,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00772729,"about_ca_topic_score_gemma":0.01793333,"domain_scores_codex":[0.9996215,0.00003635945,0.00003065843,0.0000925604,0.0001259878,0.00009302028],"domain_scores_gemma":[0.9996905,0.00005562958,0.00008477419,0.00003231917,0.00002434192,0.000112515],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006391339,0.00001082231,0.0001251453,0.00001373205,0.000003487578,0.00005307446,0.00001219065,0.00003205549,0.9994149,0.00007878406,0.00002532383,0.0001666826],"study_design_scores_gemma":[0.00004392303,0.0002424218,0.008961805,0.000006265627,0.00002129268,0.0001924212,0.00007881423,0.0003914751,0.9888245,0.00003608278,0.001191794,0.000009011753],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9937622,0.0005540334,0.001806392,0.0002447268,0.00009615938,0.00006018545,0.0008836557,0.0001264768,0.002466166],"genre_scores_gemma":[0.9876382,0.0004756227,0.001756257,0.0001951263,0.00001506076,0.00005294821,0.0006001106,0.00006492265,0.009201691],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00772729,"threshold_uncertainty_score":0.01536465,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04668338379231798,"score_gpt":0.3055214303209878,"score_spread":0.2588380465286698,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}