{"id":"W3193525805","doi":"10.1038/s41467-021-25404-x","title":"T cell receptor recognition of hybrid insulin peptides bound to HLA-DQ8","year":2021,"lang":"en","type":"article","venue":"Nature Communications","topic":"Diabetes and associated disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":51,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"Medical Research Council; National Health and Medical Research Council; Department of Health, State Government of Victoria; Australian Research Council; Victorian Cancer Agency; Australian Synchrotron; U.S. Department of Health and Human Services","keywords":"T-cell receptor; Human leukocyte antigen; T cell; Peptide; Islet; Biology; Immunology; Chemistry; Molecular biology; Cell biology; Antigen; Diabetes mellitus; Immune system; Endocrinology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007596239,0.0001983929,0.0001433538,0.0001277513,0.000101805,0.0003622413,0.0001819859,0.0002963397,0.004435045],"category_scores_gemma":[0.0002139702,0.00009683724,0.0001903855,0.000100952,0.000112839,0.0001203295,0.0002150833,0.0003293916,0.001025724],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001765639,"about_ca_system_score_gemma":0.00003659066,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003697494,"about_ca_topic_score_gemma":0.0001945377,"domain_scores_codex":[0.9998438,0.00003768855,0.000007740527,0.000041051,0.00002647604,0.00004316051],"domain_scores_gemma":[0.9999044,0.00002737123,0.00001668304,0.000008390359,0.00001355458,0.0000295856],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000139059,0.00001781977,0.002245526,0.00002208684,0.000007175689,0.0004841129,0.00003701643,0.000130859,0.9948547,0.0001063685,0.0000927241,0.001862505],"study_design_scores_gemma":[0.0002055429,0.001206473,0.0741769,0.00005219883,0.00007127137,0.009973742,0.0005346123,0.01062803,0.8942965,0.0006800983,0.00814131,0.00003335796],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976628,0.0002716227,0.0005680936,0.00002385958,0.00001172989,0.000003094577,0.00003347898,0.00001605691,0.001409251],"genre_scores_gemma":[0.9990608,0.00006005799,0.0002396661,0.00002745795,0.000005811909,0.000001819257,0.00007665456,0.000005103177,0.0005225765],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004435045,"threshold_uncertainty_score":0.01483667,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01087976079588366,"score_gpt":0.2598990368080737,"score_spread":0.24901927601219,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}