{"id":"W3193527370","doi":"10.7554/elife.68918","title":"Linker histone H1.8 inhibits chromatin binding of condensins and DNA topoisomerase II to tune chromosome length and individualization","year":2021,"lang":"en","type":"article","venue":"eLife","topic":"Genomics and Chromatin Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":47,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Cancer Research","funders":"National Human Genome Research Institute; National Institutes of Health; Cancer Research UK; Wellcome Trust; National Institute of General Medical Sciences; Wellcome; Howard Hughes Medical Institute","keywords":"Chromatin; Topoisomerase; Linker; Histone; DNA; Chromosome; Condensin; Linker DNA; Histone H1; Cell biology; Genetics; Biology; Chemistry; Molecular biology; Cohesin; Gene; Computer science","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001248502,0.000243343,0.0001898131,0.0001278595,0.0001348946,0.0003384148,0.0002644904,0.0002018575,0.001382023],"category_scores_gemma":[0.0001025608,0.0001836099,0.0001521962,0.00006980816,0.0002001296,0.0001600079,0.0002208838,0.0003907146,0.0002627391],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004234772,"about_ca_system_score_gemma":0.0002197739,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00104396,"about_ca_topic_score_gemma":0.001678766,"domain_scores_codex":[0.999881,0.00001214977,0.000009048651,0.00002837936,0.0000293838,0.00003992764],"domain_scores_gemma":[0.9999089,0.00001130715,0.00003403705,0.000009915877,0.00000921656,0.00002655763],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006122724,0.000009338911,0.0002132192,0.00001739591,0.00000423992,0.00001199413,0.000005052351,0.00005693606,0.9987761,0.00007433812,0.0000259602,0.0007442119],"study_design_scores_gemma":[0.00001223745,0.000052831,0.003434598,0.000003133035,0.000007028076,0.00004081218,0.00001220588,0.0005341436,0.9943296,0.00002998012,0.001541321,0.000002217789],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9952062,0.001611007,0.001593422,0.0001298719,0.0000219084,0.00001033477,0.0001797454,0.00006418563,0.001183327],"genre_scores_gemma":[0.996311,0.0004887425,0.0005906415,0.00004139741,0.000005217538,0.000009954118,0.0001798206,0.00001394514,0.002359256],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001382023,"threshold_uncertainty_score":0.004623353,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007774735182563754,"score_gpt":0.2445355198256973,"score_spread":0.2367607846431335,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}