{"id":"W3193527370","doi":"10.7554/elife.68918","title":"Linker histone H1.8 inhibits chromatin binding of condensins and DNA topoisomerase II to tune chromosome length and individualization","year":2021,"lang":"en","type":"article","venue":"eLife","topic":"Genomics and Chromatin Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":47,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Cancer Research","funders":"National Human Genome Research Institute; National Institutes of Health; Cancer Research UK; Wellcome Trust; National Institute of General Medical Sciences; Wellcome; Howard Hughes Medical Institute","keywords":"Chromatin; Topoisomerase; Linker; Histone; DNA; Chromosome; Condensin; Linker DNA; Histone H1; Cell biology; Genetics; Biology; Chemistry; Molecular biology; Cohesin; Gene; Computer science","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000113822,0.0001285456,0.0001824489,0.00004912397,0.000102433,0.00002260917,0.00005424862,0.0001194991,0.00002195649],"category_scores_gemma":[0.0001062187,0.0001394037,0.00002830144,0.0001054467,0.0000564326,0.000004735544,0.0002612157,0.00005192639,0.000002490287],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000151188,"about_ca_system_score_gemma":0.00007184432,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000092274,"about_ca_topic_score_gemma":0.00006045648,"domain_scores_codex":[0.9991661,0.00003102244,0.0002473564,0.0002854819,0.0001199581,0.0001500926],"domain_scores_gemma":[0.9994797,0.000009511486,0.00009742226,0.0001993132,0.000109617,0.0001045113],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000007048978,0.00004392709,0.001290397,0.00004557039,0.00003444123,0.000003970652,0.0004701785,0.00001822054,0.9969662,0.0001725683,0.0002764704,0.000671043],"study_design_scores_gemma":[0.0006691736,0.0002236424,0.006089538,0.00003984218,0.00002683736,0.00005128652,0.0001764724,0.0002272191,0.9857661,0.0000293936,0.006483091,0.0002174093],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9981694,0.0009206981,0.0001731038,0.0002499793,0.00008648248,0.0001173187,0.00006762586,0.000007788743,0.0002076137],"genre_scores_gemma":[0.996639,0.0004070359,0.001764999,0.0003679034,0.00008377725,0.000004993035,0.000284916,0.00002120015,0.0004261596],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01120007,"threshold_uncertainty_score":0.5684718,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007774735182563754,"score_gpt":0.2445355198256973,"score_spread":0.2367607846431335,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}