{"id":"W3193529142","doi":"10.1186/s13568-021-01276-8","title":"Production of R- and S-1,2-propanediol in engineered Lactococcus lactis","year":2021,"lang":"en","type":"article","venue":"AMB Express","topic":"Microbial Metabolic Engineering and Bioproduction","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"JST-Mirai Program; Adaptable and Seamless Technology Transfer Program through Target-Driven R and D; Institute of Genetics; RIKEN; Japan Science and Technology Agency; National Brain Research Centre","keywords":"Lactococcus lactis; Metabolic engineering; Kluyveromyces lactis; Lactic acid; Nisin; Chemistry; Food science; 1,3-Propanediol; Bacteria; Biochemistry; Fermentation; Biology; Yeast; Saccharomyces cerevisiae; Enzyme","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001986354,0.0007014447,0.000451188,0.0002320981,0.0001095802,0.0005353632,0.0002807354,0.0003209983,0.0002578889],"category_scores_gemma":[0.0001823551,0.0001672788,0.0004311362,0.0002914178,0.0001702114,0.0002772448,0.0004791286,0.0005105766,0.0002339323],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003863432,"about_ca_system_score_gemma":0.0003338837,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001134782,"about_ca_topic_score_gemma":0.001549867,"domain_scores_codex":[0.9997727,0.00002914302,0.00003298315,0.00004609692,0.00007302727,0.00004594821],"domain_scores_gemma":[0.9998842,0.00001401815,0.00004374674,0.00001114526,0.0000178866,0.0000289603],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002397216,0.00002363086,0.00009905822,0.00002307201,0.00000282414,0.00005414562,0.000009229082,0.00007541934,0.9991165,0.00001799306,0.000009000179,0.0005451425],"study_design_scores_gemma":[0.000005155352,0.0001242157,0.0005187335,0.000003844803,0.000009591164,0.00009315853,0.00002200283,0.0006366245,0.9979062,0.00001104168,0.0006647592,0.000004664212],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9935907,0.0007753785,0.004201107,0.00009519367,0.00003114621,0.00003183602,0.0003124214,0.00009388743,0.0008684494],"genre_scores_gemma":[0.9857428,0.000558449,0.01035599,0.000050682,0.000009073549,0.00003015465,0.0007859659,0.00004554063,0.002421459],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001134782,"threshold_uncertainty_score":0.002803147,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00631525349772237,"score_gpt":0.2156870647998311,"score_spread":0.2093718113021087,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}