{"id":"W3193542749","doi":"10.1126/scitranslmed.abd5750","title":"ALT neuroblastoma chemoresistance due to telomere dysfunction–induced ATM activation is reversible with ATM inhibitor AZD0156","year":2021,"lang":"en","type":"article","venue":"Science Translational Medicine","topic":"Neuroblastoma Research and Treatments","field":"Medicine","cited_by":58,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Cancer Institute; CANDU Owners Group; Cancer Prevention and Research Institute of Texas; Alex's Lemonade Stand Foundation for Childhood Cancer","keywords":"Gene knockdown; Telomere; Cancer research; Neuroblastoma; Chemistry; Biology; Cell culture; Genetics; Gene; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002814047,0.0002359055,0.0003357202,0.0003641182,0.0003810111,0.00003346969,0.0001545384,0.00004563422,0.0008284292],"category_scores_gemma":[0.0003235951,0.0001758422,0.00005415298,0.003006828,0.0004375521,0.0004607094,0.00002853548,0.0002622414,0.0001083348],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000162683,"about_ca_system_score_gemma":0.001224896,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003803123,"about_ca_topic_score_gemma":0.00005526721,"domain_scores_codex":[0.9963545,0.00003880742,0.0002969066,0.0007839301,0.002022,0.0005038826],"domain_scores_gemma":[0.9979475,0.000142818,0.00007316136,0.0004061504,0.0008097655,0.0006205628],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001633122,0.0003376901,0.004025269,0.0001205049,0.0000674514,0.0005895526,0.0007167198,0.00003749498,0.9802082,0.0005143254,0.003329712,0.008420026],"study_design_scores_gemma":[0.006534475,0.002324148,0.2729333,0.0008671096,0.00009492279,0.0005871053,0.000269963,0.0002933411,0.7126377,0.0004542926,0.002716085,0.0002875584],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9355842,0.00005442194,0.00103341,0.05573848,0.0002207849,0.0006202624,0.00001484318,0.00007672765,0.006656889],"genre_scores_gemma":[0.9925101,0.00000912761,0.002484485,0.002715497,0.000295721,0.00003898916,0.00003392879,0.00002580841,0.001886365],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2689081,"threshold_uncertainty_score":0.9070719,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02724939853901355,"score_gpt":0.3013424853623377,"score_spread":0.2740930868233241,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}