{"id":"W3193552583","doi":"10.1101/2021.08.23.457385","title":"Cell Sex and Sex Hormones Modulate Kidney Glucose and Glutamine Metabolism in Health and Diabetes","year":2021,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Hormonal Regulation and Hypertension","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; University of Manitoba; Children's Hospital Research Institute of Manitoba; Université Laval; University of Toronto; Toronto General Hospital; University Health Network","funders":"Instituto de Salud Carlos III; Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; University Health Network","keywords":"Endocrinology; Glutamine; Internal medicine; Biology; Glucose homeostasis; Hormone; Oxidative stress; Kidney; Glutathione; Diabetes mellitus; Medicine; Insulin resistance; Biochemistry; Amino acid","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002070187,0.0001586963,0.0002340773,0.0002423645,0.0001769767,0.0004138464,0.00009115228,0.0002036814,0.00278015],"category_scores_gemma":[0.000145717,0.0001033879,0.0001859034,0.00023714,0.000151648,0.0001504689,0.0002036325,0.0002373753,0.0006159674],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001441805,"about_ca_system_score_gemma":0.0001551162,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004988311,"about_ca_topic_score_gemma":0.0005858386,"domain_scores_codex":[0.9999212,0.00001274065,0.000003830929,0.00002125996,0.00002220279,0.00001877594],"domain_scores_gemma":[0.9999281,0.0000102236,0.00001721096,0.00001076036,0.00001244222,0.00002129883],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000811937,0.00005229262,0.0183268,0.0001913149,0.00005466252,0.0005184074,0.0001977989,0.0002234161,0.9543038,0.001326616,0.001799043,0.02219392],"study_design_scores_gemma":[0.00006810205,0.0003715919,0.3976575,0.00005410181,0.0001200883,0.001556029,0.0005387519,0.002398989,0.5618772,0.002605409,0.03271341,0.00003876003],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9654118,0.01529566,0.007611295,0.001261755,0.0004678637,0.00002212547,0.002908949,0.0002563149,0.006764286],"genre_scores_gemma":[0.9818278,0.004395352,0.001720796,0.0001717737,0.0001150096,0.00001745792,0.001039304,0.00005944418,0.01065308],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00278015,"threshold_uncertainty_score":0.00930047,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0120440455540506,"score_gpt":0.2193898820742795,"score_spread":0.2073458365202289,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}