{"id":"W3193567633","doi":"10.1084/jem.20210360","title":"The germinal center reaction depends on RNA methylation and divergent functions of specific methyl readers","year":2021,"lang":"en","type":"article","venue":"The Journal of Experimental Medicine","topic":"RNA modifications and cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":48,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Benoziyo Endowment Fund for the Advancement of Science; European Research Council; Lundbeckfonden; Weizmann Institute of Science; Novo Nordisk Fonden; Azrieli Foundation; Israel Science Foundation; Irma und Jacques Ber-Lehmsdorf - Stiftung; Gerald O. Mann Charitable Foundation; European Molecular Biology Organization","keywords":"Methylation; Germinal center; Center (category theory); RNA methylation; Biology; Genetics; Chemistry; Methyltransferase; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003421178,0.0000616309,0.00008731274,0.00002408452,0.0001220135,0.00000458996,0.0000713855,0.00002860451,0.00003611538],"category_scores_gemma":[0.00003287089,0.00003235568,0.00004062504,0.00005709386,0.0001298849,0.000005018213,0.00002314971,0.00008426652,6.568167e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002253751,"about_ca_system_score_gemma":0.00002301751,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000007521271,"about_ca_topic_score_gemma":0.000002935373,"domain_scores_codex":[0.9993659,0.0001004789,0.0002261655,0.00006901954,0.0001730525,0.00006544168],"domain_scores_gemma":[0.9994635,0.00003680225,0.0001952652,0.0001598084,0.0001068129,0.00003784158],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002756032,0.00005363002,0.00005231295,0.000001397388,0.00005452157,0.000001171125,0.0003150086,0.000007477074,0.9908968,0.0000661509,0.002605495,0.00567044],"study_design_scores_gemma":[0.0006293661,0.0006206867,0.002176793,0.00002799181,0.00003710712,0.0001073924,0.007142887,0.000005181446,0.95474,0.00002521705,0.03445125,0.00003611937],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9751512,0.02073354,0.0006181335,0.001862346,0.0004725553,0.00005110778,0.000002640446,8.756906e-7,0.001107544],"genre_scores_gemma":[0.9937547,0.00530677,0.00005257268,0.00008940038,0.000329911,0.000002060924,0.000008327428,0.000005427532,0.0004508105],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03615678,"threshold_uncertainty_score":0.1319426,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02828234677498439,"score_gpt":0.3052951229348796,"score_spread":0.2770127761598952,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}