{"id":"W3193593859","doi":"10.21203/rs.3.rs-659023/v1","title":"Autophagy promotes cell survival by maintaining NAD(H) levels","year":2021,"lang":"en","type":"preprint","venue":"Research Square","topic":"Autophagy in Disease and Therapy","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Biotechnology and Biological Sciences Research Council; Medical Research Council; LifeArc; Surgical Reconstruction and Microbiology Research Centre; LEO Fondet; National Institute for Health and Care Research; National Institutes of Health; Japan Society for the Promotion of Science; National Health and Medical Research Council; Cancer Research UK; Fundação de Amparo à Pesquisa do Estado de São Paulo; Wellcome Trust; Emerald Foundation; UK-India Education and Research Initiative","keywords":"Autophagy; NAD+ kinase; Cell biology; Cell survival; Chemistry; Cell; Biology; Biochemistry; Apoptosis; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001159701,0.0002548421,0.0002407202,0.000287131,0.0002961013,0.0003422763,0.0001303991,0.0001794669,0.006803674],"category_scores_gemma":[0.00009471806,0.00006788422,0.0001354794,0.0002296402,0.0001802494,0.0001681335,0.0002705803,0.0002704008,0.002981306],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000286498,"about_ca_system_score_gemma":0.0002101268,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005397291,"about_ca_topic_score_gemma":0.0008289586,"domain_scores_codex":[0.9999472,0.000007179015,0.000002811815,0.00001249257,0.00002009392,0.00001012875],"domain_scores_gemma":[0.9999629,0.000008025855,0.000005097215,0.000005559898,0.000009136369,0.000009196388],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004342704,0.00004425838,0.0004611288,0.0002144295,0.00001490185,0.0003361618,0.00003107279,0.0003554042,0.9769014,0.002438994,0.003601629,0.01516638],"study_design_scores_gemma":[0.00006367451,0.000139895,0.006056375,0.00003120984,0.00001957744,0.0007434213,0.00005145442,0.00390354,0.9417829,0.00276708,0.04443189,0.000009084392],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8788737,0.0163189,0.03105588,0.002200247,0.001560132,0.00006732198,0.005603068,0.002460701,0.06186006],"genre_scores_gemma":[0.9467554,0.003568942,0.009733776,0.0001407694,0.0001303329,0.00002628077,0.00222968,0.000196433,0.03721828],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006803674,"threshold_uncertainty_score":0.02276051,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08983013065220195,"score_gpt":0.4198457689897349,"score_spread":0.3300156383375329,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}