{"id":"W3193617819","doi":"10.2139/ssrn.3877395","title":"Calcium-Dependent ESCRT Recruitment and Lysosome Exocytosis Maintain Epithelial Integrity During <i>Candida albicans</i> Invasion","year":2021,"lang":"en","type":"article","venue":"SSRN Electronic Journal","topic":"Antifungal resistance and susceptibility","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Hospital for Sick Children","funders":"","keywords":"ESCRT; Candida albicans; Exocytosis; Autophagy; Lysosome; Cell biology; Biguanide; Microbiology; Biology; Chemistry; Endosome; Biochemistry; Endocrinology; Secretion; Apoptosis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001331558,0.0002591696,0.0003871536,0.0001981785,0.0003927978,0.0009768184,0.0003449329,0.0006897348,0.003429276],"category_scores_gemma":[0.0002792045,0.0002177802,0.0003480535,0.0002000112,0.0002574265,0.0007292552,0.0005126223,0.001058258,0.001479791],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007100587,"about_ca_system_score_gemma":0.0005381177,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001867506,"about_ca_topic_score_gemma":0.003474702,"domain_scores_codex":[0.9997082,0.00002039333,0.00002028471,0.00005534133,0.0000649281,0.0001308165],"domain_scores_gemma":[0.9998314,0.00001527103,0.00004148873,0.00002665351,0.00003851448,0.00004658284],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003109349,0.00002449976,0.0003590711,0.00003187468,0.000004654227,0.0001428867,0.00003089606,0.00005345451,0.9966468,0.0003374568,0.0003869749,0.00167058],"study_design_scores_gemma":[0.00003552637,0.0001235004,0.02975794,0.00001882898,0.00001263383,0.0003857998,0.0001904171,0.001392339,0.9629318,0.0002190984,0.004918004,0.00001426212],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9849287,0.001781129,0.004765266,0.0004832252,0.0001106223,0.0000638003,0.001133881,0.000283216,0.006450227],"genre_scores_gemma":[0.9892069,0.0003865082,0.001370628,0.0001358791,0.00002085544,0.00004747981,0.0007183381,0.00008738232,0.008025981],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003429276,"threshold_uncertainty_score":0.01147205,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03014330468382779,"score_gpt":0.2858464132623449,"score_spread":0.2557031085785171,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}