{"id":"W3193644143","doi":"10.1021/acsinfecdis.1c00175","title":"Design and Evaluation of New Quinazolin-4(3<i>H</i>)-one Derived PqsR Antagonists as Quorum Sensing Quenchers in <i>Pseudomonas aeruginosa</i>","year":2021,"lang":"en","type":"article","venue":"ACS Infectious Diseases","topic":"Bacterial biofilms and quorum sensing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":42,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"Innovate UK; National Biofilms Innovation Centre; Biotechnology and Biological Sciences Research Council; Joint Programming Initiative on Antimicrobial Resistance; Engineering and Physical Sciences Research Council; Medical Research Council; European Commission; Wellcome Trust","keywords":"Quorum sensing; Pseudomonas aeruginosa; Virulence; Chemistry; Microbiology; Quorum Quenching; Isothermal titration calorimetry; Cross-resistance; Biology; Biochemistry; Bacteria; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003341438,0.0004432483,0.0003975076,0.0001652869,0.0002059685,0.0004125796,0.0006278893,0.0003713849,0.002317751],"category_scores_gemma":[0.0002034291,0.000168253,0.0002447937,0.0001563606,0.0002362603,0.0002923819,0.0002358091,0.0006005911,0.0005804246],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000445776,"about_ca_system_score_gemma":0.0005652738,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008545142,"about_ca_topic_score_gemma":0.002239263,"domain_scores_codex":[0.9998665,0.00002907813,0.000009931715,0.00002459073,0.00003373476,0.00003617741],"domain_scores_gemma":[0.9999126,0.000007169612,0.00002540699,0.000007419646,0.00002378103,0.00002352916],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005211983,0.0003141137,0.0003229682,0.0002178341,0.00002292231,0.0001690074,0.00005142178,0.002552794,0.9787201,0.001040888,0.0007990872,0.01526771],"study_design_scores_gemma":[0.0006066169,0.0101342,0.001906269,0.0000476965,0.00008404938,0.0004853213,0.00005724508,0.004926663,0.9579493,0.0003116726,0.02343696,0.00005399441],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9446501,0.0085779,0.03204155,0.001101952,0.0001571751,0.001970385,0.002357093,0.0004525166,0.008691276],"genre_scores_gemma":[0.9608596,0.005509824,0.02345207,0.0003397272,0.0000257521,0.0005862275,0.002329537,0.00004645951,0.006850669],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002317751,"threshold_uncertainty_score":0.00775367,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01970071442448751,"score_gpt":0.2708596302428287,"score_spread":0.2511589158183412,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}