{"id":"W3193644143","doi":"10.1021/acsinfecdis.1c00175","title":"Design and Evaluation of New Quinazolin-4(3<i>H</i>)-one Derived PqsR Antagonists as Quorum Sensing Quenchers in <i>Pseudomonas aeruginosa</i>","year":2021,"lang":"en","type":"article","venue":"ACS Infectious Diseases","topic":"Bacterial biofilms and quorum sensing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":42,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"Innovate UK; National Biofilms Innovation Centre; Biotechnology and Biological Sciences Research Council; Joint Programming Initiative on Antimicrobial Resistance; Engineering and Physical Sciences Research Council; Medical Research Council; European Commission; Wellcome Trust","keywords":"Quorum sensing; Pseudomonas aeruginosa; Virulence; Chemistry; Microbiology; Quorum Quenching; Isothermal titration calorimetry; Cross-resistance; Biology; Biochemistry; Bacteria; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002635559,0.0001866074,0.0002391885,0.00005675733,0.00008462472,0.00005295198,0.00004880892,0.0001511631,0.00001574503],"category_scores_gemma":[0.0003514276,0.0002098621,0.00006434553,0.0001734414,0.00009520493,0.000013548,0.00009166029,0.00007456585,0.000002801939],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004184685,"about_ca_system_score_gemma":0.0006771809,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004170109,"about_ca_topic_score_gemma":0.0002877431,"domain_scores_codex":[0.998558,0.0002881712,0.0002727359,0.0004065438,0.0002120383,0.0002624724],"domain_scores_gemma":[0.9991823,0.0000408866,0.0001280345,0.0002725393,0.0002418241,0.0001344079],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001118317,0.0001102791,0.006451323,0.00002432585,0.00006180295,0.00001530869,0.00008707403,0.000275882,0.9802267,0.00002146279,0.0001756636,0.01243833],"study_design_scores_gemma":[0.001672272,0.0001825489,0.01603954,0.00007351743,0.0001715393,0.00009518604,0.0001194166,0.0001326041,0.9804917,0.0004680711,0.0002823896,0.0002712079],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9962035,0.002542917,0.0003196335,0.0001910509,0.0001950663,0.0002604127,0.000009703746,0.00001931028,0.0002583689],"genre_scores_gemma":[0.9978524,0.000668523,0.0008475157,0.0003059714,0.0001528383,0.000003543179,0.0001136999,0.00002406157,0.00003142962],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01216713,"threshold_uncertainty_score":0.855793,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01970071442448751,"score_gpt":0.2708596302428287,"score_spread":0.2511589158183412,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}