{"id":"W3193674176","doi":"10.1111/liv.15039","title":"Seladelpar improved measures of pruritus, sleep, and fatigue and decreased serum bile acids in patients with primary biliary cholangitis","year":2021,"lang":"en","type":"article","venue":"Liver International","topic":"Liver Diseases and Immunity","field":"Medicine","cited_by":89,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto General Hospital; University Health Network","funders":"Medical Research Council; National Institute for Health and Care Research","keywords":"Medicine; Visual analogue scale; Internal medicine; Gastroenterology; Quality of life (healthcare); Bile acid; Agonist; Sleep disorder; Receptor; Physical therapy; Insomnia; Pharmacology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000488291,0.0003113042,0.0006694532,0.0001367402,0.0001465678,0.0001982441,0.0001190271,0.0002118444,0.002372063],"category_scores_gemma":[0.0008035023,0.0001164418,0.0003907525,0.0001574393,0.0001505717,0.0002170931,0.0001590309,0.0004922447,0.0001952211],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001345214,"about_ca_system_score_gemma":0.0001632248,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002608892,"about_ca_topic_score_gemma":0.0007684343,"domain_scores_codex":[0.9998385,0.00007632156,0.00001811235,0.00001777406,0.00002612924,0.00002313479],"domain_scores_gemma":[0.999665,0.0001258966,0.00009684354,0.00001620682,0.00003404355,0.0000619548],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.1192742,0.01442659,0.2021777,0.003009589,0.001933616,0.00153325,0.001537872,0.001901265,0.1205545,0.0001007289,0.00279931,0.5307514],"study_design_scores_gemma":[0.01515118,0.1901097,0.7790882,0.0000919662,0.0007750696,0.001868072,0.0003525107,0.0009041395,0.00799528,0.00006131928,0.003569196,0.00003335067],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976028,0.001296127,0.0000759963,0.00009312389,0.00001334818,0.00005339354,0.0000977699,0.0000238362,0.0007437828],"genre_scores_gemma":[0.9986978,0.0004537102,0.0002044466,0.0001075648,0.00001827976,0.00002618147,0.0001287217,0.000002114442,0.0003612534],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002372063,"threshold_uncertainty_score":0.007935345,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01400152682852013,"score_gpt":0.2255617995956079,"score_spread":0.2115602727670877,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}